Abstract Number: PB1372
Meeting: ISTH 2020 Congress
Theme: Platelet Disorders and von Willebrand Disease » Acquired Thrombocytopenias
Background: Dengue an arbovirus disease has become an episodic epidemic in Pakistan since 2005.The Neurological manifestations < 1 % 1 however this can be misleading as actual incidence of CNS manifestations has not yet been reported from developing countries.
Aims: This study was conducted to review the number of patients presented with different neurological manifestation of dengue in Pakistan.
Methods: This retrospective literature review was structured by compiling data of dengue infected patients presenting with different neurological complaints i.e, headache, confusion, seizures, intracranial bleeds,stoke and hematoma (CT/MRI diagnosed ) in organized questinare. Data available from ICU, general surgery and neurosurgery department of government and private tertiary healthcare centers were compiled from 2011 to 2019.All these patients were multiple transfused with RCC,FFP and platelet concentrates.
Results: We divided our study population(1582 patients ) into 2 groups,first group consisted of 1458 (92%) patients that were managed conservatively. Platelets counts of these patients ranged from 12 to 52,000 cmm though we did not find any positive correlation between platelets count and CNS presentation (p value>.05). 36 patients (2.4%) died from group 1. While in second group 73 (4.6%) patients only 12 (16%) had emergency neurosurgery while 61 (83%) patients mostly elderly and children ( significant p>.05) died as specialized treatment is expensive and not readily available at all hospitals that dealt with dengue epidemics in Pakistan.
Conclusions: Through experience dealing with dengue hemorrhagic fever has improved survival but the mortality still high in neurological affected patients as evident from data of epidemics. New national health policy for prevention as well as medical insurance is required according to changing world anticipated epidemics in coming years.
To cite this abstract in AMA style:
Imran T, Altaf H, Meraj L. Pattern of Central Nervous System Involvement an Emerging Allied Complications of Dengue Hemorrhagic Fever. A literature Review [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/pattern-of-central-nervous-system-involvement-an-emerging-allied-complications-of-dengue-hemorrhagic-fever-a-literature-review/. Accessed October 1, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/pattern-of-central-nervous-system-involvement-an-emerging-allied-complications-of-dengue-hemorrhagic-fever-a-literature-review/