Abstract Number: PB1921
Meeting: ISTH 2020 Congress
Background: Thrombosis of the dorsal vein of the penis is a rare disorder that affects males in the age range between 20-70 years.
Aims: We present the first case report in literature involving a man diagnosed with Penile Mondor’s disease (PMD) and antiphospholipid syndrome (APS).
Methods: A 38y man developed persistent pain in his penis after intense sexual activity and he visited an urologist. Clinical and ultrasound examination revealed thrombosis of the superficial dorsal vein of the penis. The patient then was referred to our hemostasis unit for management.
Results: The patient had negative personal history, but his brother was heterozygous in Prothrombin G20210A mutation with two DVTs.
His blood count, coagulation values, antithrombin, protein C and S were normal and inherited thrombophilia was discovered. An APAs panel test was performed. Elevated titres of IgM aCL
(31.1 MPL, normal< 20MPL) were found which were confirmed 12 weeks later. Neither IgG aCL antibodies nor lupus anticoagulant nor IgG/M antiβ2 GPI antibodies were found.
We managed him by administering LMWH in prophylactic dose (Bemiparin 3,500 IU/day). One month later repeat ultrasound examination revealed complete recanalization of the lesion and rivaroxaban was suggested to the patient.
Conclusions: PMD is a rare male disease. Transection of the vessel during surgery or any type of trauma such as external compression may trigger its possible development.
This disease usually is self-limiting. In the acute phase, sexual activity should be restricted in addition to the use of anticoagulation. Creams containing heparin and anti-inflammatory drugs are used in the chronic phase. No permanent sequel has been defined in long-term. Thrombectomy and resection of the superficial penile vein are applied surgically in patients refractory to the medication.
To our knowledge this is the first documented case report of a patient with PMD and documented APS, making his therapeutic approach and monitoring a real challenge.
To cite this abstract in AMA style:Karavalakis G, Papadakis E, Karamanos D, Efstratiadou M, Tigkiropoulos K, Kioumi A. Penile Mondor’s Disease Associated with Anticardiolipid Antibodies: A Very Rare Case of Antiphospholipid Syndrome [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/penile-mondors-disease-associated-with-anticardiolipid-antibodies-a-very-rare-case-of-antiphospholipid-syndrome/. Accessed October 2, 2023.
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