Abstract Number: PB0530
Meeting: ISTH 2020 Congress
Background: Analysis of responsiveness to antiplatelet therapy is crucial in the management of patients with cardiovascular disease.
Aims: This study aimed to evaluate a new platelet function analysis system (Anysis-200) and to compare it with VerifyNow (Accumetrics, San Diego, CA) in cardiology patients.
Methods: A total of 125 citrated blood samples were collected from 85 cardiology patients who were referred for platelet function testing. In Anysis-200, platelet function was measured as blood migration distance (MD) until clogging of flow passage, which is comparable to aspirin resistance units obtained using VerifyNow. The two devices were simultaneously used and compared.
Results: The MDs before and after taking aspirin were 174±51 and 247±27 mm, respectively
(p< 0.0001). Compared with VerifyNow (reference), the sensitivity and specificity of Anysis-200 was 91.5% and 75.5%, respectively (area under the curve, 0.829). Further, the true positive rate in patients newly taking aspirin was 85% for VerifyNow and 92.5% for Anysis-200, respectively. The Cohen's kappa coefficient between the two devices was 0.682, indicating a relatively high agreement.
Conclusions: Anysis-200, a novel system for assessing platelet aggregation, has accuracy and precision equivalent to that of, and significant agreement with, VerifyNow. Anysis-200 may be useful in screening patients with abnormal platelet reactivity and aspirin nonresponsiveness.
To cite this abstract in AMA style:Xu S, Piao J, Lim C-, Lee BK, Han C, Na S, Shin S. Performance Evaluation of Anysis-200 Platelet Function Analyzer in Cardiology Patients [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/performance-evaluation-of-anysis-200-platelet-function-analyzer-in-cardiology-patients/. Accessed October 2, 2023.
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