Abstract Number: PB1310
Meeting: ISTH 2021 Congress
Background: The association between aPL and PIH remains unclear and controversial. There is no general agreement on which aPL profile confers the greatest obstetric risk and its relationship with perinatal outcome in comparison with patients at same gestational age without aPL. Current treatment fails in 20-30% of pregnancies.
Aims: To assess prospectively the impact of aPL on perinatal outcome in control normal pregnant women studied after 20 weeks and patients hospitalized for PIH and studied at time of its diagnosis.
Methods: Normal pregnant women (NP) (n=40): >20 weeks of gestation, without infection, hypertension, autoimmune disease, antithrombotic drugs, thromboembolic and/or pregnancy complications, delivering a newborn (NB) at term with adequate birthweight (bw) for gestational age (GA). Patients: Hospitalized for PIH (n=100). Laboratory tests: Blood samples were taken at the time of PIH onset and after 20 w of gestation. Lupus anticoagulant (LA) according to the ISTH recommendations; ELISA tests aPL Ig G and IgM (Louisville) anti b2 Glycoprotein I antibodies IgG and IgM (ab2GPI). GA and bw were documented, and statistical analysis results are showed in table.
Results: Results: LA was positive in 24% of PIH and in 5% of NP (p <0.01). Only Ig M ab2GPI was significantly higher: 5, 57 ± 3, 21 UI/ml vs 7, 77 ± 4, 57UI/ml (p<0.01). GA and BW between NP and PIH
See Table: Perinatal results of aPL in PIH and normal pregnant women
Conclusions: Gestational age is an indicator of perinatal morbimortality. In our work LA was strongly associated with early PIH, but we did not found differences between the gestational age in women with and without aPL and with PIH.
To cite this abstract in AMA style:Grand B, Voto LS. Perinatal Outcome of Normal Pregnant and Pregnant Women Hospitalized for Hypertension (PIH: Pregnancy Induced Hypertension) and Studied for Antiphospholipid Antibodies (aPL) at Time of PIH Onset [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/perinatal-outcome-of-normal-pregnant-and-pregnant-women-hospitalized-for-hypertension-pih-pregnancy-induced-hypertension-and-studied-for-antiphospholipid-antibodies-apl-at-time-of-pih-onset/. Accessed January 23, 2022.
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