Background: The VTE prophylaxis rate in hospitalized patients is low. System-wide multifaceted quality improvement intervention may be an efficient strategy to optimize the VTE prophylaxis.

Aims: To explore the effectiveness of multifaceted quality improvement intervention in VTE prophylaxis in hospitalized patients.

Methods: Hospitalized patients admitted in the department of respiratory and critical care medicine, orthopedic, and general surgery wards were allocated into two groups based on their department admitted. The intervention group received regular care combined with multifaceted quality improvement intervention. The control group implemented the hospital’s current VTE prophylaxis measures. We analyzed the improvement of VTE risk assessment rate, the VTE prophylaxis rate, and the occurrence of hospital-related VTE events.

Results: A total of 3,644 eligible patients were enrolled in the study. The VTE prophylaxis rate of the intervention group increased from 22.93% to 34.56% (P < 0.001), and the incidence of HA-VTE events increased from 0.49% to 1.00% (P=0.366). In the control group, the VTE prophylaxis rate increased from 21.65% to 27.16% (P=0.091), and the incidence of HA-VTE events increased from 0.47% to 2.02% (P=0.001).

Conclusion(s): Multifaceted quality improvement intervention strategy is expected to facilitate implementation of recommended VTE prophylaxis and reducing the incidence of HA-VTE incidents in hospital. However, it is necessary to conduct more multi-center clinical trials in the future to provide more reliable real-world evidence.

Image

Improvement in VTE risk assessment and VTE prophylaxis

Image

Change in in-hospital HA-VTE Event from baseline to the end of intervention

« Back to ISTH 2022 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/pilot-study-of-effect-on-thromboprophylaxis-using-system-wide-multifaceted-quality-improvement-intervention-based-on-clinical-decision-support-system-in-hospitalized-patients/