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Plasma Levels of P-Selectin and Future Risk of Venous Thromboembolism

1Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø – The Arctic University of Norway, Tromsø, Norway, Tromsø, Troms, Norway, 2UiT - The Arctic University of Norway, Tromsø, Troms, Norway, 3Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Oslo, Norway, 4Thrombosis Research Center, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway, Tromso, Troms, Norway, 5UiT – The Arctic University of Norway, Tromso, Troms, Norway

Abstract Number: PB1339

Meeting: ISTH 2022 Congress

Theme: Venous Thromboembolism » VTE Epidemiology

Background: Elevated P-selectin levels have been observed following acute venous thromboembolism (VTE) and are reported to predict recurrent VTE and cancer-associated VTE. Whether plasma P-selectin levels are associated with risk of future incident VTE in the general population remains unclear.

Aims: To investigate the association between plasma P-selectin levels and risk of future incident VTE.

Methods: We performed a nested case-control study in 415 VTE patients and 843 age- and sex-matched controls derived from the general population (Tromsø IV cohort 1994-2007). The levels of soluble P-selectin were measured in plasma samples collected at baseline (1994/95) using ELISA. Samples were categorized according to quartile cut-offs in the control population. Logistic regression models were used to estimate odds ratios (OR) for VTE across quartiles of plasma P-selectin in overall- and sex-stratified analysis after adjustment for age, sex, body mass index and C-reactive protein levels.

Results: We found no association between P-selectin levels in plasma and risk of VTE in the overall analyses. However, sex-stratified analyses revealed that women with plasma P-selectin levels in the highest quartile (>44.3 ng/mL) had higher risk of VTE (OR 1.63, 95% CI: 1.01-2.64) compared with women with plasma P-selectin levels in the lowest quartile (≤29.9 ng/mL) (Table 1). In contrast, higher levels of P-selectin were apparently associated with lower risk of VTE in men (OR for highest vs. lowest quartile of P-selectin: 0.69, 95% CI: 0.42-1.15). The observed associations were stronger when the time between blood sampling and VTE was shorter (Figure 1).

Conclusion(s): Our findings suggest that elevated levels of plasma P-selectin are associated with an increased risk of future VTE in women but not in men.

Table

Table 1. Odds ratios -OR- with 95% confidence intervals -CI- for venous thromboembolism -VTE- according to quartiles of plasma levels of P-selectin

Image

Figure 1. Plots of estimated ORs for overall VTE in all subjects, men, and women as a function of time from blood sampling in the fourth survey of the Tromsø Study -1994-5- and VTE event in analyses adjusted for age, sex, and BMI. Blue circles indicate ORs with p-values < 0.05.

To cite this abstract in AMA style:

Swamy S, Brækkan S, Ueland T, Hansen J, Snir O. Plasma Levels of P-Selectin and Future Risk of Venous Thromboembolism [abstract]. https://abstracts.isth.org/abstract/plasma-levels-of-p-selectin-and-future-risk-of-venous-thromboembolism/. Accessed October 1, 2023.

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