Abstract Number: PB1384
Meeting: ISTH 2020 Congress
Background: The need for monitoring of the effect of antiplatelet drug and for prediction of hemorrhage in pre-surgical/perioperative patients lead to development of different platelet function testing (PFT) assays.
Aims: To compare light transmission aggregometry (LTA) and PFA-200 system in monitoring of the antiplatelet treatment.
Methods: A total of 68 patients taking antiplatelet drugs for at least 6 weeks (45 patients with aspirin 100mg/day and 23 with clopidogrel 75mg/day) were tested with LTA and PFA-200 system in parallel. LTA assay measures from 0% to 100% platelet residual activity (RA). PFA-200 measures the prolongation of the closure time (CT) in seconds (s) (Col/EPI test > 150s = positive effect of aspirin; < 150s = no effect. PFA P2Y test > 106s = positive effect of clopidogrel; < 106s = no effect). Platelet count and hematocrit were within the normal range. Patients did not take other drugs that could impact the PFT result.
Results: LTA results for aspirin showed satisfactory drug effect in 77.7% (5%-30% RA), borderline effect in 17.7% (50-70% RA) and no effect in 4.4% of the patients. LTA results for clopidogrel showed satisfactory effect in 74% (5%-30% RA), borderline effect in 21.7% (50-70% RA) and no effect in 4.3% of the patients. According to the PFA-200 results, positive effect of aspirin
(190s-300s) and of clopidogrel (160s-300s) was observed in 77.7% and in 69.5% of the patients respectively; no effect was observed in 22.2% and in 30.4% of the patients respectively. In patients with borderline LTA result, no antiplatelet effect was registered by the PFA-200.
Conclusions: PFA-200 seems to be more suitable as a point-of-care tool for assessment of perioperative bleeding risk caused by a severe platelet dysfunction. LTA is laboratory standard to diagnose platelet function disorders and to monitor the effect of antiplatelet drugs.
To cite this abstract in AMA style:Makarovska Bojadjieva T, Useini S, Velkova E, Todorovska E, Nikolova J, Ristovska E, Petkovik E, Grubovic R. Platelet Function Assay PFA-200 for Monitoring of Antiplatelet Drug Effect [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/platelet-function-assay-pfa-200-for-monitoring-of-antiplatelet-drug-effect/. Accessed January 21, 2022.
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