Abstract Number: PB0883
Meeting: ISTH 2022 Congress
Background: Hypertriglyceridemia is associated with hypercoagulability, but the association between triglyceride levels and altered platelet function remains unclear.
Aims: The aim of this study was to assess the association between platelet function and triglyceride levels.
Methods: We included participants from the Framingham Heart Study (FHS) Third Generation cohort, New Offspring Spouse (NOS) and OMNI cohort who attended the third examination cycle (2016-2019). Eligible participants were categorized into four triglyceride (TG) subgroups. We assessed platelet responses to adenosine diphosphate using flow cytometry and light transmission aggregometry. In addition, the levels of thrombogenicity were determined using the novel Total Thrombus formation Analysis System (TTAS).
Results: The study included 1897 (55.53%) FHS participants with normal TG levels (TG levels < 100 mg/dL); 883 (25.85%) participants with high-normal TGs (TG levels 100-150 mg/dL); 378 (11.06%) with borderline high TGs (TG levels>150-199 mg/dL); and 258 (13.60%) participants with HTG (TG levels>200 mg/dL) (Table 1). In our linear mixed effects model adjusted for age, sex, alcohol consumption, aspirin use, and statin use, TG levels were associated with decreased platelet P-selectin exocytosis (CD62P) (b= 0.006, p=0.022). Similarly in the subgroup analysis %CD62P levels were inversely associated with borderline-high TG (b=-1.155, p=0.0095), and high TG levels b=-1.188, p=0.0071). Lastly, high-normal, and borderline-high TG levels were associated with increased levels of collagen-dependent thrombogenicity (b=0.236, p=0.0006) measured with TTAS.
Conclusion(s): TG levels are associated with altered platelet activation and aggregation even at TG levels considered as normal. Furthermore, increased platelet-driven thrombogenicity is directly associated with TG levels.
To cite this abstract in AMA style:Nkambule B, Chan M, Lachapelle A, Thibord F, Cunha J, Pashek R, Chen M, Johnson A. Platelet reactivity and thrombogenicity in Framingham Heart Study participants with hypertriglyceridemia [abstract]. https://abstracts.isth.org/abstract/platelet-reactivity-and-thrombogenicity-in-framingham-heart-study-participants-with-hypertriglyceridemia/. Accessed September 29, 2023.
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