Abstract Number: PB0661
Meeting: ISTH 2020 Congress
Background: Severe burns cause profound hemostasis. An objective assessment of the state of the hemostatic system is the key to effective treatment of patients.
Aims: To study the relationship of thromboelastogram indices with generally accepted coagulological tests in patients with severe burn injury.
Methods: The state of the endothelial, coagulation, anticoagulant and fibrinolytic links of the hemostatic system (ACL TOP 500 analyzer), the viscoelastic properties of the blood (thromboelastograph TEG 500, tests using a coaline activator and heparinase), were determined in 233 patients with burns over 20% of the body surface and in 20 healthy people.
Results: The studies have shown that the hemostatic system reacts with a sharp increase in procoagulant activity, endothelial dysfunction, oppression of anticoagulant mechanisms as a response to severe thermal damage. The highest sensitivity was revealed to the following tests: von Willebrand factor (FW) activity was 100%, XIIa-dependent fibrinolysis (XIIa-df) – 95%, fibrinogen (Fg) – 72%, antithrombin III (AT III) – 65%, TEG (alpha, MA and G) – 44%, APTT, thrombin time, prothrombin time, TEG (R and k) – less than 20%. Analysis of the correlation between TEG indices and standard coagulogram tests revealed a moderate relationship between APTT and R (r = 0.42, p = 0.001), Fg and MA (r = 0.47, p = 0.001), Fg and G (r = 0.48, p = 0.001). There was no correlation with FW, ATIII, XIIa- df.
Conclusions: Thromboelastography is not an alternative to advanced coagulological studies. At the same time, it is an indispensable tool for verifying the cause of hypocoagulation in patients with severe burn injury.
To cite this abstract in AMA style:Presnyakova M, Kostina O. Possibilities of Thromboelastography in Patients with Severe Burns [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/possibilities-of-thromboelastography-in-patients-with-severe-burns/. Accessed September 29, 2023.
« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/possibilities-of-thromboelastography-in-patients-with-severe-burns/