Abstract Number: PB2093
Meeting: ISTH 2020 Congress
Background: Pulmonary embolism (PE) has been demonstrated to increase the incidence and prevalence of atrial fibrillation (AF) through right sided cardiac pressure overload and elevated cytokines.
Aims: We sought to investigate predictive accuracy of complete blood count (CBC) indices and ratios in differentiating patients with preexisting versus new onset atrial fibrillation after presenting acute PE episode.
Methods: Acute PE patients were divided into 3 groups: prior diagnosis of AF (n=26), patients who developed AF after PE (n=26), and patients who do not develop AF (n=247). CBC indices as well as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and platelet to neutrophil ratio (PNR) were compared in these three groups.
Results: Hemoglobin were overall significantly different between the PE patients with a prior diagnosis of AF, PE patients who did not develop AF, and PE patients with a subsequent diagnosis of AF (10.7±0.5 vs. 12.5±0.2 vs. 12.5±0.4, p=0.0028). Hemoglobin was significantly lower in PE patients with a prior diagnosis of AF compared to PE patients who did not develop AF (p=0.0019) and PE patients who did develop AF (p=.0361). Hemoglobin was significantly lower in PE patients with a prior diagnosis of AF compared to PE patients who did not develop AF (p=0.0032). RDW was overall significantly different a prior diagnosis of AF, PE patients who did not develop AF, and PE patients with a subsequent diagnosis of AF (17.0±0.7 vs. 15.4±0.2 vs. 15.0±0.3, p=0.0491). RDW was significantly higher in PE patients with a prior diagnosis of AF compared to PE patients who did not develop AF (p=0.0432).
Conclusions: Decreased levels of Hgb and hematocrit as well as increased RDW indicates that patients with preexisting AF may have an increased amount of inflammation that necessitates bone marrow compensation.
To cite this abstract in AMA style:Patel D, Slajus B, Hoppensteadt D, Phan T, Fareed J, Syed M, Darki A. Predictive Value of CBC Indices in Determining Risk of Atrial Fibrillation After Pulmonary Embolism [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/predictive-value-of-cbc-indices-in-determining-risk-of-atrial-fibrillation-after-pulmonary-embolism/. Accessed October 1, 2023.
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