ISTH Congress Abstracts

Official abstracts site for the ISTH Congress

MENU 
  • Home
  • Congress Archive
    • ISTH 2021 Congress
    • ISTH 2020 Congress
  • Resources
  • Search

Predictors of the Development of the Post-thrombotic Syndrome: A Sub-analysis of the ATTRACT Trial

F. Rinfret1,2, C.-S. Gu3, S. Vedantham4, S. Kahn2,1

1McGill University, Montreal, Canada, 2Jewish General Hospital, Montreal, Canada, 3Centre for Regulatory Excellence, Statistics and Trials, Ottawa, Canada, 4Washington University School of Medicine, St. Louis, United States

Abstract Number: LPB0091

Meeting: ISTH 2021 Congress

Theme: Venous Thromboembolism » Post-thrombotic Syndrome

Background: The post-thrombotic syndrome (PTS) occurs in 30-40% of patients following deep vein thrombosis (DVT). Factors such as sex, older age, elevated body mass index (BMI) and ipsilateral prior DVT have previously been identified as strong predictors of PTS.

Aims: To investigate known and novel predictors of the development of PTS in participants of the ATTRACT Trial, which evaluated pharmacomechanical catheter-directed thrombolysis plus anticoagulation vs. anticoagulation alone to treat proximal DVT.

Methods: Using the ATTRACT Trial database, we used multivariate logistic regression to identify baseline and post-baseline factors that were predictive of the development of PTS during study follow-up, as defined by a Villalta score ≥5 from 6-24 months after enrolment.

Results: Among 691 study participants, median age was 53 years and 62% were male. In the multivariate analysis, age (OR 1.03 per year increase [95% CI 1.02 to 1.04]) and BMI (OR 1.05 per 1kg/m2 [95% CI 1.02 to 1.07]) were independent predictors of PTS. Additional predictors identified were Villalta score at baseline (OR 1.09 per 1-unit increase [95% CI 1.05 to 1.13]), leg pain severity at day 10 (OR 1.28 [95% CI 1.13 to 1.45] per 1 point increase in a 7-point scale) and employment status (unemployed due to disability OR 3.31 [95% CI 1.72 to 6.35] vs. employed >35 hours per week). Use of rivaroxaban on day 10 appeared to be protective (OR 0.53 [95% CI 0.33 to 0.86]) when compared to warfarin.  

Conclusions: We confirmed that age and BMI were predictors of PTS in the ATTRACT population. We also identified that baseline Villalta score, leg pain severity at 10 days, and unemployed due to disability are independent predictors of PTS. Our findings also suggest that the initial choice of anticoagulant to treat DVT may have an impact on the development of PTS.

To cite this abstract in AMA style:

Rinfret F, Gu C-, Vedantham S, Kahn S. Predictors of the Development of the Post-thrombotic Syndrome: A Sub-analysis of the ATTRACT Trial [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/predictors-of-the-development-of-the-post-thrombotic-syndrome-a-sub-analysis-of-the-attract-trial/. Accessed May 20, 2022.

« Back to ISTH 2021 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/predictors-of-the-development-of-the-post-thrombotic-syndrome-a-sub-analysis-of-the-attract-trial/

Simple Search

Supported By:

Bristol Myers Squibb and Pfizer

ISTH 2021 Congress site

Visit the official web site for the ISTH 2021 Virtual Congress »

  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2022 John Wiley & Sons, Inc. All Rights Reserved.
Wiley