Abstract Number: PB1263
Meeting: ISTH 2020 Congress
Background: Vitamin K deficiency bleeding (VKDB) remains a serious but preventable problem worldwide with a high risk of mortality or permanent disability especially among exclusively breastfeeding infants.
Aims: This was a cross sectional hospital-based study to determine the prevalence and management approach to the newborns with classical and late VKDB that occur after second day of life (DOL).
Methods: All the newborns delivered from January-June 2018 in NICU of Aga khan university hospital; Karachi Pakistan and presented with active bleed after second DOL, were enrolled in study. Prothrombin time (PT) and international normalized ratio (INR) were monitored after 24 hours of birth, at active bleed and after VK therapy. VK 1mg prophylactic dose given within 1-6 hours of delivery irrespective of birth weight (BW). Intravenous VK 3mg and 5mg was given once daily for 3days to neonates with BW up to 2000g and >2000g respectively.
Results: All neonates received prophylactic VK. Total of 105(19%) neonates of 552 had active bleed after second day of life. 98(93%) neonates presented with prolonged PT and INR at active bleed. 38 (36%) of up to 2000g BW received 3mg and 67(63%) with > 2000g received 5 mg therapeutic doses. 38(36.2%) received fresh frozen plasma too. PT & INR normalized in 90 neonates with 3days VK therapy. 7 were given second cycle of VK therapy with in 14 DOL. Only total of 12 neonates with active bleed were diagnosed with other than VKDB. Statistically the number of neonates with > 2000g was significantly high with VKDB. No correlation was found between the GA and VKDB.
Conclusions: VK deficiency is highly prevalent among newborn babies in the population studied. These findings further highlight the importance of regular screening of neonates for VK deficiency and may be higher prophylactic doses required specially in neonates with > 2000g BW.
To cite this abstract in AMA style:Ambreen G, Hussain K, Javed S, Sohail M, Naz Z, Muhammad Waqar H, Iazaz U, Aziz Ahmad K, Saboor Hussain A, Moiz Hussain A. Prevalence and Management Approach to the Newborn with Classical and Late Vitamin K Deficiency Bleeding (VKDB) in LMIC [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/prevalence-and-management-approach-to-the-newborn-with-classical-and-late-vitamin-k-deficiency-bleeding-vkdb-in-lmic/. Accessed November 26, 2020.
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