Abstract Number: PB0625
Meeting: ISTH 2021 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Scientific evidence describes that primary prophylaxis can reduce the incidence of hemophilic arthropathy and its impact on quality of life. In Colombia, starting with Law 100 of 1993, a comprehensive social security regime was implemented; in the case of hemophilia, coverage went from 15% in 1993 to 98% in 2012. In 2003, prophylaxis was generalized, achieving that in 2015 more than 90% of patients had treatment regardless of their age.
Aims: The objective was to evaluate the association between primary prophylaxis and hemophilic arthropathy in Colombian men with hemophilia A (HA).
Methods: Retrospective descriptive study with a total of 90 patients with severe / moderate HA without inhibitors who were distributed into two groups: primary and secondary / tertiary prophylaxis, in a health service provider institution (Integral Solutions SD).
Results: The median age was 20.5 years, the median at diagnosis 1 year, the dose of FVIII used was 27.8 (IU / Kg / dose) with a significant difference between primary (25.0) and secondary prophylaxis / tertiary (28.6). There were no differences in the frequency of prophylaxis application. The ABR of the cohort was 0.81 without significant differences between the 2 groups. The prevalence of hemophilic arthropathy in the study cohort was 42.2% (n = 38) with a significant difference (p value 0.00) between primary (0.0%) versus secondary / tertiary prophylaxis (55.1%). A greater tendency to have arthropathy was observed in patients diagnosed before 2004, the date on which prophylaxis was widely implemented in Colombia.
Conclusions: Giving patients early prophylaxis with factor VIII concentrates can prevent not only bleeding, but also joint damage, in turn generating a better quality of life. This decrease in joint damage could be evidenced after prophylaxis with coverage and efficacy was implemented in Colombian patients starting in 2004.
To cite this abstract in AMA style:
Diaz Mosquera GA, Sarmiento Doncel S, Cortes JM, Meza FJ, Peña JE, Agudelo Rico C, Ramirez Plazas N, Montaño Mejia CA, Perdomo Amar IA, Maza Villadiego A, Parrado Rey A. Primary Prophiliaxis was Associated with a Lower Risk of Joint Damage in Colombian Men Patients with Hemophilia A [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/primary-prophiliaxis-was-associated-with-a-lower-risk-of-joint-damage-in-colombian-men-patients-with-hemophilia-a/. Accessed April 25, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/primary-prophiliaxis-was-associated-with-a-lower-risk-of-joint-damage-in-colombian-men-patients-with-hemophilia-a/