Background: The safety, quality and supply of donor-derived platelet units intended for transfusion have improved over the past decades but significant problems still remain. In vitro-derived platelets offer a possible alternative but up-scaling production is hindered by our limited understanding of thrombopoiesis (the release of platelets by their mother cell, the megakaryocyte) Aims: Here, we … Continue reading Production of platelets in vitro in functionalised 3-dimensional scaffolds mimicking the bone marrow niche