Background: Pediatric patients with lymphoma are in the higher risk of symptomatic venous thromboembolism (sVTE) compared with patients with other malignancies except acute lymphoblastic leukemia.

Aims: To evaluate pediatric lymphoma patients with high risk of sVTE.

Methods: Our study is a monocentric retrospective analysis of 262 patients aged < 18 years with lymphoma that were treated in our Center since 2013 to 2019 year. Chi-square test has been used for comparison of qualitative variables, Mann-Whitney test - for comparison of quantitative variables. Risk factors were analyzed by univariate and multivariate analysis with logistic regression. ROC-analysis was used for the determination of optimal cutoff. P-value < 0.05 was considered as significant.

Results: In an univariate analysis such factors as age (12.1±4.2 years vs 10.3±4.7 years; p=0.009) with optimal cut-off 12 years, non-O blood group (10.3%, 95%CI: 5.8-14.8% vs 3.4%, 95%CI: 0-7.2%; p=0.084), the volume of mediastinal mass (OR=1.075; 95%CI: 1.01–1.143, р=0.02 for every 100 ml increment) with the optimal cutoff 250 ml, mean body mass index (BMI, 20.7±5.1 vs 17.9±3.8 kg/m2, p=0.005) with optimal cutoff 18 kg/m2 and ICU admittance during the first 30 days of hospitalization (ICU+) due to life-threatening condition (OR=3.96; 95%CI: 1.396–11.252, р=0.01) were statistically significant associated with sVTE risk and subsequently included in the multivariate model (table 1).

The optimal cutoff for “high risk group of sVTE” was ≥11 points. The cumulative incidence of sVTE in “high risk” and “standard risk” groups are presented in the figure 1.

Conclusion(s): The model developed in our Center allows to stratify pediatric patients with lymphoma in “high risk group of sVTE”.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/prognostic-model-for-predicting-the-risk-of-symptomatic-venous-thromboembolism-in-children-and-adolescents-with-lymphoma/