Background: A poor prognosis of concomitant courses of arterial hypertension and diabetes mellitus type 2 on the population morbidity especially deals with the thrombotic complications which are situated in locally injured vessels.

Aims: To set von Willebrand factor (vWF) level at the patients with arterial hypertension (AH) and type 2 diabetes mellitus (DM) and analyze its prognostic relationship due to vasodilation and assessment of endothelial function.

Methods: The activity of vWF was estimated in plasma of 146 patients with AH and DM and in 50 healthy persons using specific standardized VWF-reagent. The research of endothelial dysfunction was conducted in flow-mediated dilatation. Prognostic level of VWF was analyzed in the true-positive rate test and, then, with plotting a function of receiver operating characteristic.

Results: Initially, it was set, that basal level of vWF at patients with AH and type 2 DM was reliably higher (113,3±13,9%) than in the control group (85,2±8,9%; р<0,01). It was determined the negative reliable association in vWF activity and index of absolute diameter increasing (r=-0,49, р=0,02). Then we have measured sensitivity, specificity and, set the predictive value of vWF level in relation to disorders of endothelial function. The prognostic value of the model was sufficiently high, area under the curve (AUC) obtains 64,6%±6,74% (р=0,015), that is a difference to 50,0% of AUC level. It was set the prognostic points for  vWF activity between 81,5 % and 131,0 %.

Conclusions: The results undertaken in the study testify that elevation of vWF activity is associated with the decline of absolute increase of brachial diameters in flow-mediated dilatation test with prognostic level of vWF between 81,5% and 131,0%.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/prognostic-significance-of-von-willebrand-factor-in-flow-mediated-dilatation-test-at-patients-with-arterial-hypertension-and-diabetes-type-2/