Abstract Number: PB1822
Meeting: ISTH 2020 Congress
Theme: Role of Hemostatic System in Cancer, Inflammation and Immunity » Platelets and Inflammation
Background: Septic shock is a life-threatening disease associated with high mortality.
Aims: To identify the prognostic value of the different platelet-derived parameters.
Methods: The study was conducted in a 28-beded intensive care unit (ICU) of a university hospital. All Adult patients admitted with sepsis or septic shock were included. Two citrated blood samples were collected on admission from consented patients and processed immediately using Sinnowa PL-12. Two platelets parameters were measured [Platelet count (PLT) and Mean Platelet Volume (MPV)] before and after the addition of four agonists [Arachidonic acid (AA), Adenosine diphosphate (ADP), Collagen and Epinephrine]. Maximum aggregation rate (MAR)% calculated as following: [1-(lowest platelet count/initial platelet count)] x 100. The variation of MPV after exposure to each agonist (delta MPV) was also calculated. Demographic data were also recorded. Two groups were compared: survivors and dead at discharge from ICU.
Results: Forty-seven cases were included. Median age was 57[39-74] years. Median SOFA score was 6[2-9]. Median platelets count on admission was 258[151-346] G/L. Median MPV was 8[8-9.6]. Ten patients (21.3 %) experienced disseminated intravascular coagulation. Twelve patients died (ICU mortality = 25.5 %). (MAR)% was similar between dead and survivors after exposure to AA (26.4[17.6-31.8] versus 42.4[22.9-57.6]; p=0.056), after exposure to ADP (22.9[17.6-30.7] versus 35[21.6-49.7]; p=0,127) and after exposure to epinephrine (26.1[16.3-34.5] versus 37.5[23.5-45.4]; p=0,151). Delta MPV was significantly higher after exposure to AA (0.4[0.1-0,54] versus 0,8[0.3-1.3]; p = 0.03) but not after exposure to ADP (0,2[0,1-0,67] versus 0.5[0.1-0.9]; p=0.166) nor epinephrine (0.4[0.1-0.7] versus 0.7[0.1-0.9]; p=0.577). ROC curve analysis shows that Delta MPV post-AA > 0.54 predicts mortality with a sensitivity of 62 % and a specificity of 63 %.
Conclusions: MPV variation after AA exposure is a useful marker for predicting mortality in septic patients.
To cite this abstract in AMA style:
Alharbi G, Chaari A, Cox D. Prognostic Value of Platelet-Derived Parameters in Septic Patients: A Prospective Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/prognostic-value-of-platelet-derived-parameters-in-septic-patients-a-prospective-study/. Accessed September 29, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/prognostic-value-of-platelet-derived-parameters-in-septic-patients-a-prospective-study/