Abstract Number: PB2149
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » Cancer Associated Thrombosis
Background: Cerebral gliomatosis (CG) are a group of rare infiltrative tumor entity of the brain whose prognosis is reserved.
Aims: Thromboembolic event (TE) as a presenting manifestation of this entity is exceptional excluding the post-operative context.
Methods: We present a new case of cerebral glial tumor revealed by pulmonary embolism.
Results: A 53-year-old man presented with respiratory distress secondary to a pulmonary embolism (PE). Chest CT scan showed several micronodules without any malignant feature, Abdominopelvic ultrasound showed hypertrophy of the prostate and cervical ultrasound was normal. Tumor markers (AFP, ACE,CA 19-9 antigen, PSA) were normal. The patient was treated with heparin and anti-vitamin K drugs. Three weeks after the diagnosis of PE, he was admitted to the emergency room for generalized convulsions without trauma or fever. Laboratory tests were normal and brain imaging showed cerebral gliomatosis.
He was treated with corticosteroids 20 mg/day and valproic acid. A stereotaxic biopsy to determine the phenotype of the CG could not be achieved. The patient died 18 months after the onset of the diagnosis in a context of intracranial hypertension.
Conclusions: The association between venous thromboembolic diseases and neoplasia is widely established however the discovery of a cerebral gliomatosis as neoplastic etiology of the VTE is rare. Indeed, the thromboembolism events are common in the postoperative period in cerebral neoplasia and specifically in glial tumors. TE accidents associated with these pathologies are generally attributed to the postoperative context, corticosteroid treatment or the chemotherapy. This observation is particular by the occurrence of the VTE as a first manifestation of the disease.
To cite this abstract in AMA style:
Mrouki M, Cherif Y, Derbel S, Ben Dahmen F, Abdallah M. Pulmonary Embolism as a Presenting Manifestation of Cerebral Glial Tumor [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/pulmonary-embolism-as-a-presenting-manifestation-of-cerebral-glial-tumor/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/pulmonary-embolism-as-a-presenting-manifestation-of-cerebral-glial-tumor/