Abstract Number: PB0176
Meeting: ISTH 2021 Congress
Background: Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) in late December 2019, there has been increasing recognition of the pro-thrombotic risk this virus can cause as part of Coronavirus disease 2019
Aims: To assess if the rate of PTE was increased in those with COVID-19 in both critical care and ward patients.
To assess the effect of right heart strain or requirement for critical care on mortality.
Methods: We reviewed all computed tomography pulmonary angiograms (CTPA) performed in Scotland between 23rd March and 31st May 2020 (1st wave) and identified those inpatients with COVID-19 using either classical radiological appearances, or positive COVID-19 polymerase chain reaction swab.
3401 CTPAs were reviewed. 192 were positive for PTE in patients with evidence of COVID-19 either real-time polymerase chain reaction (RT-PCR) swab positive for SARS-CoV-2 [n=104] or having radiological changes consistent with COVID-19 [n=88]). The total number of hospital admissions in Scotland between 23rd March 2020 and 31st May 2020 with COVID-19 was 5195. The incidence of PTE during this time was 3.7% in all patients admitted to all hospitals in Scotland with COVID-19 during this period. 475 hospitalised patients were managed in critical care (both level 2 and level 3 care), in whom the incidence of PTE was 6% (n=29). 4720 patients required ward based care alone and the incidence of PTE was 3.5% (n=163). This compares to the national pre-Covid rate of 1%. There was increased risk of death with right heart strain (25/52 vs 128/140[p<0.01]) and in critical care (15/29 vs 146/163[p<0.01]).
Conclusions: In this national study, we have demonstrated an increased risk of pulmonary thromboembolism in both critical care and ward based environments.
To cite this abstract in AMA style:McGettrick M, MacLellan A, McCaughey P, Bagot C, Brewis M, N Lang N, Johnson M, Church AC. Pulmonary Thromboembolism (PTE) in Hospitalised Patients with COVID-19: A National Study of Patients Managed in Critical Care and Ward Environments [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/pulmonary-thromboembolism-pte-in-hospitalised-patients-with-covid-19-a-national-study-of-patients-managed-in-critical-care-and-ward-environments/. Accessed September 29, 2023.
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