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Quality of life after a first venous thrombosis in elderly

1Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, 2Larner College of Medicine at the University of Vermont, Colchester, Vermont, United States, 3Department of Clinical Epidemiology, Leiden University Medical Center, Leiden University, Leiden, the Netherlands, Leiden, Zuid-Holland, Netherlands, 4Leiden University, Medical Center, Leiden, Zuid-Holland, Netherlands

Abstract Number: PB1340

Meeting: ISTH 2022 Congress

Theme: Venous Thromboembolism » VTE Epidemiology

Background: Limited information exists regarding short and long-term effects of venous thrombosis on quality of life in the elderly.

Aims: To assess the impact of a first venous thrombosis on quality of life in older patients with venous thrombosis.

Methods: Analyses were performed in the AT-AGE study, a multi-center case-control study performed in Vermont, USA and Leiden, NL, comprising of 401 cases with a first VT and 431 control subjects, all aged ≥70 years. We measured health-related quality of life using the generic SF-36 questionnaire. All patients filled in the questionnaire twice, i.e., soon after the venous thrombosis (visit 1) and one year after the venous thrombosis (visit 2) while controls filled in the questionnaire once. We used a difference of ≥5 points in any subscale of the SF36 as clinically or socially relevant. The study was approved by the Medical Ethical Committee of the Leiden University Medical Center and by the Committee of Human Research of the University of Vermont.

Results: Except for mental health, the quality of life of patients was decreased after their VT compared with that of controls (visit 1: mean difference for physical score: -15.9 (-19.3 to -12.4)) and for mental score: -12.5(-15.7 to -9.3)) (Table). Apart from general health, the quality of life of patients was improved in the year after venous thrombosis, i.e., the physical score was 49.5(46.9-52) at visit 1 and 55.2(52.4-58) at visit 2 (Figure).

Conclusion(s): Quality of life of patients soon after the venous thrombosis was impaired in all domains (except for mental health) compared with the controls in the elderly. Quality of life of patients was improved one year after the venous thrombosis (except for general health). More detailed analysis regarding disease specific quality of life will be available at ISTH conference.

The Table

Quality of life of SF-36 questionnaire at visit 1

The image

The difference between two visits of SF-36 in venous thrombosis patients

To cite this abstract in AMA style:

Wang H, Cushman M, Rosendaal F, van Hylckama Vlieg A. Quality of life after a first venous thrombosis in elderly [abstract]. https://abstracts.isth.org/abstract/quality-of-life-after-a-first-venous-thrombosis-in-elderly/. Accessed October 1, 2023.

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