Abstract Number: PB/CO18
Meeting: ISTH 2020 Congress
Background: Coronavirus disease 2019 (COVID-19) was associated with venous thromboembolic events (VTE).
Aims: To determine the incidence VTE among hospitalized patients with COVID-19 before and after changes in thromboprophylaxis.
Methods: A retrospective study was performed to the University Hospital of Lausanne for patients admitted with COVID-19 from February 28 to April 30, 2020. Because the level of awareness of VTE complications related to COVID-19 rose rapidly during the pandemic period, the study period was divided in three periods: first period from February 28 to March 25 (low awareness of SARS-CoV-2 thrombogenic potential), second from March 26 to April 5 (increased level of awareness), and third from April 6 to May 5 (intermediate intensity thromboprophylaxis in ICU patients).
Results: Among 450 admitted patients with COVID-19, VTE were diagnosed in 41 patients (27 pulmonary embolisms, 12 deep vein thrombosis, one pulmonary embolism and deep vein thrombosis, one portal vein thrombosis). VTE occurred within 72 hours from admission in 18 (43.9%) patients and later during the hospital stay in 23 (56.1%) patients. A total of 171 chest CT-scans were performed in 135 patients. Figure 1 illustrates the daily number of performed CT and VTE diagnosed upon admission and within 72h (1A) or after 72h of hospitalization (1B, 1C). During hospitalization, CT-scans performed during hospitalization increased steadily throughout the three periods. However, while VTE diagnoses per 1’000-patient-days increased from the first to second period, a decrease was observed from the second to the third one (Table). Specifically, 22 ICU-admitted patients developed VTE (six early and 16 late VTE). Thirteen late VTE occurred under standard-of-care thromboprophylaxis (18.5 per 1’000 ICU-days) and three under intermediate intensity thromboprophylaxis (4.9 per 1’000 ICU-days; P 0.040).
Conclusions: This reduction of VTE diagnoses could reflect the effect of more aggressive anticoagulation strategies implemented in ICU hospitalized patients on April 6, 2020.
|Period 1 (February 28 to March 25)||Period 2 (March 26 to April 5)||Period 3 (April 6 to May 7)|
|Upon admission and within 72h|
|VTE per 100-admissions||1.1||6.8||5.2|
|During hospitalization (after 72h from admission)|
|VTE per 1’000-patient-days||1.8||7.7||3.4|
[CT-scan and VTE per 100-admissions or per 1’000-patient-days in the three periods]
To cite this abstract in AMA style:Filippidis P, Kampouri E, Viala B, Méan M, Pantet O, Desgranges F, Tschopp J, Regina J, Karachalias E, Bianchi C, Zermatten M, Jaton K, Qanadli SD, Bart P-, Pagani J-, Guery B, Papadimitriou-Olivgeris M, Alberio L. Reduction of Venous Thromboembolic Events in Hospitalized Patients with Coronavirus Disease 2019 after Intensification of Thromboprophylaxis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/reduction-of-venous-thromboembolic-events-in-hospitalized-patients-with-coronavirus-disease-2019-after-intensification-of-thromboprophylaxis/. Accessed March 3, 2021.
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