Abstract Number: PB2568
Meeting: ISTH 2020 Congress
Background: Pregnancy is known to be associated with significant changes in the coagulation and fibrinolytic systems. As the consequence, the reference ranges defined in healthy adult population are not optimal for ensuring proper diagnosis of both hemorrhagic and thrombotic complications in pregnant women.
Aims: To define the reference ranges for coagulation parameters during pregnancy and puerperium period in women from the Krasnoyarsk area (Siberia, Russian Federation).
Methods: Blood samples were collected once from a total of 324 women (mean age=29.5 years, range: 18-43), during a routine visit related to their pregnancy (n=261) or during puerperium (n=63), after their informed consent was obtained. None had any complication during pregnancy, delivery, or puerperium. Samples were obtained at different time of pregnancy i.e. gestational weeks 1-12 (n=35), 13-21 (n=43), 22-28 (n=66), 29-34 (n=59), and 35-42 (n=58), as well as during postpartum day 1 (n=31) and day 3 (n=32). A control group of non-pregnant women was also evaluated (n=64). Routine and esoteric coagulation parameters were performed on a fully automated analyzer ACL TOP (IL) i.e. prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, factor (F)II,FV,FVII,FIX,FX,FXI,FXII, von Willebrand factor (vWF:Ag), D-dimers, antithrombin, protein C, free protein S and plasminogen, using reagents from the analyzer manufacturer.
Results: Pregnancy was associated with significantly shortened PT and aPTT when compared to non-pregnant women. Significant changes were demonstrated for most specific parameters. Particularly, the plasma levels of fibrinogen, D-dimers, FVIII FIX, FXII and vWF:Ag significantly correlated with gestational age, whereas free PS was negatively correlated. Altogether, these results suggested a prothrombotic state du during pregnancy. Even if changes in some parameters were amplified in the first days, a trend toward normalization was observed for most parameters during puerperium.
Conclusions: The use of gestational age-specific reference ranges is critical for the accurate interpretation of hemostatic tests during pregnancy and puerperium.
To cite this abstract in AMA style:Potylitsina V, Raspopin Y, Olkhovsky I, Toulon P. Reference Ranges for Hemostasis Parameters during ¨Pregnancy and Puerperium [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/reference-ranges-for-hemostasis-parameters-during-%c2%a8pregnancy-and-puerperium/. Accessed October 19, 2021.
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