Abstract Number: PB0505
Meeting: ISTH 2022 Congress
Theme: Arterial Thromboembolism » Cardiovascular Risk Factors
Background: Obesity and depression are intertwined diseases often associated with increased risk of cardiovascular (CAD) complications. Despite modifications in the Brain-Derived Neurotrophic Factor (BDNF) levels in the brain have been observed in subjects with depression and obesity, the relationships among peripheral BDNF, depression and obesity are not well-defined, yet. Changes in extracellular vesicle (EV)-derived miRNAs in blood have been related to obesity, depression and CAD.
Aims: In this study, we investigated the association among BDNF, depression and EV-derived miRNAs related to atherothrombosis.
Methods: 743 overweight/obese individuals (BMI>25 kg/m2) of the SPHERE cohort were analyzed. A standard biochemical evaluation was assessed. BDNF plasma levels were measured by ELISA, EV-miRNA isolated from plasma and analysed by TaqMan™ OpenArray™. Depression state was evaluated by the Beck Depression Inventory-II (BDI-II).
Results: In multivariate analysis, a negative association between BDNF and depression was found (p=0.0004), and this relationship was modified by the high levels of inflammatory marker IF1, suggesting that a potential protective activity of BDNF is dependent on the high inflammatory levels. From the analysis of EV-derived miRNAs emerged a clear that BDNF associated with about 80 upregulated and 59 downregulated miRNAs known to be related to cardiovascular diseases. miRNA target analysis showed that 18 of these genes fall in the atherothrombotic dataset. Interestingly, a network between genes involved in coagulation and inflammation specifically PTGS2, MTHFR, TNF-a, IL6, IL1b, SERPIN1, PLAT, TFPI, TF and BDNF was found.
Conclusion(s): Overall these data provide a robust association among depression score, obesity, indicating and BDNF plasma levels, and support the hypothesis of a critical link between circulating BDNF levels and atherothrombotic risk.
To cite this abstract in AMA style:
Barbieri S, Amadio P, Macchi C, Zarà M, Favero C, Solazzo G, Vigna L, Greco M, Buoli M, Siroti C, Ieraci A, Ruscica M, Bollati V. Relation among Brain Derived Neurotrophic Factor, depression, and extracellular vesicles-derived miRNA – results from an Italian cohort [abstract]. https://abstracts.isth.org/abstract/relation-among-brain-derived-neurotrophic-factor-depression-and-extracellular-vesicles-derived-mirna-results-from-an-italian-cohort/. Accessed March 21, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/relation-among-brain-derived-neurotrophic-factor-depression-and-extracellular-vesicles-derived-mirna-results-from-an-italian-cohort/