Abstract Number: PB2042
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » Atrial Fibrillation
Background: The restriction of oral vitamin K (VK) intake is said to be essential for patients with warfarin anticoagulation. However, until now, the ideal daily intake of VK for each patient was not well established.
Aims: In this study, we evaluated the correlation between warfarin control and daily VK intake from the perspective of the VK epoxide reductase complex subunit 1 (VKORC1) genotype.
Methods: We enrolled 84 patients (29 females, average age 75.6) taking warfarin for more than one year. The serum VK concentration and VKORC1 genotype were evaluated with informed consent, and the original questionnaire about the average daily food menu was contrived to estimate the daily VK intake. The baseline characteristics of each patient were also extracted and analyzed.
Results: The VKORC1 genotype AA and AG were found in 81% and 19% respectively. None of our patients had GG genotype. All patients with AG took daily VK less than 250µg and the daily VK intake among AA patients distributed in a wide range (50-600µg). Both VK concentration and average warfarin dosage in patients with AG were significantly higher than those with AA (p<0.001). Whereas there existed a significant correlation between VK concentration and total VK intake in patients with AG (p<0.001), there was no correlation in patients with AA. Also, we found a significant correlation between VK intake and average warfarin dosage in patients with AG, no correlation was found in patients with AA. In spite of these results, the difference in average TTR in both genotypes was not significant.
Conclusions: The influence of daily oral VK intake for warfarin treatment was recognized only among patients with VKORC1 AG genotype. For patients with AG, the daily intake of VK up to 250µg is acceptable, furthermore, a strict restriction of VK may not need among those with AA.
To cite this abstract in AMA style:
Nagao T, Yasunishi K, Kumagai H, Kodani E, Kimura K. Relationship between TTR and Daily Vitamin K Intake in Patients Taking Warfarin: The Difference among VKORC1 Genotype [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/relationship-between-ttr-and-daily-vitamin-k-intake-in-patients-taking-warfarin-the-difference-among-vkorc1-genotype/. Accessed October 2, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/relationship-between-ttr-and-daily-vitamin-k-intake-in-patients-taking-warfarin-the-difference-among-vkorc1-genotype/