Abstract Number: OC 34.3
Meeting: ISTH 2021 Congress
Theme: Venous Thromboembolism » VTE Epidemiology
Background: A prior venous thrombosis (VT) is associated with the risk of a recurrent VT, but the evidence for this in the literature rarely comes from studies with longer than 10 years of follow-up.
Aims: To evaluate the association between VT > 10 years ago and risk of VT in older age.
Methods: Analyses were performed in the AT-AGE study, a multi-center case-control study performed in Vermont, USA and Leiden, NL, comprising of 460 VT cases and 456 controls, aged ≥70 years. To assess the risk of VT associated with a self-reported history of VT, odds ratios (OR) with 95% confidence intervals (CI) were calculated, after adjustment for age, sex, body mass index (BMI) and study center. All participants provided written informed consent. The study was approved by the Medical Ethical Committee of the Leiden University Medical Center and the Committee of Human Research of the University of Vermont.
Results: Compared with those without a history of VT, individuals with a history of VT > 10 years prior to the index date (current VT for cases and date of inclusion for controls) had a 2.7-fold (95%CI, 1.6-4.6) increased risk of VT. The risk did not differ with time since previous event, i.e., individuals with a VT 10-30 years ago had a 3.0-fold increased risk of VT (95%CI, 1.4-6.4); individuals with a VT more than 30 years ago had a 2.3-fold increased risk of VT (95%, 1.1-4.8). A VT>10 years ago was associated with a more pronounced risk of DVT than PE±DVT, and for unprovoked than provoked events (Table 1). The association between a history of VT >10 years ago and a current VT was similar after stratification by age at index date (Table 2).
Table 1 | ||||||||
---|---|---|---|---|---|---|---|---|
Patients N=460 |
Controls N=456 |
OR crude (95%CI) |
*OR total (95%CI) |
*OR DVT (95%CI) |
*OR PE±DVT (95%CI) |
*OR provoked (95%CI) |
*OR unprovoked (95%CI) |
|
No prior VT | 401 | 431 | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) |
Any VTE>10y ago | 59 | 25 | 2.5(1.6-4.1) | 2.7(1.6-4.6) | 3.5(1.9-6.3) | 2.1(1.1-3.9) | 1.4(0.7-2.8) | 3.9(2.2-6.8) |
No prior VT | 401 | 431 | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) |
Any VTE 10-30y ago# | 28 | 11 | 2.7(1.3-5.6) | 3.0(1.4-6.4) | 3.3(1.4-7.7) | 2.6(1.1-6.1) | 2.1(0.8-5.3) | 3.4(1.5-7.7) |
Any VTE>30y ago# | 27 | 12 | 2.4(1.2-4.8) | 2.3(1.1-4.8) | 2.9(1.2-7.0) | 1.8(0.8-4.3) | 0.9(0.3-2.7) | 3.8(1.7-8.3) |
Table 2 | ||||
---|---|---|---|---|
Patients N=460 |
Controls N=456 |
OR crude (95%CI) |
*OR (95%CI) |
|
No prior VT | 401 | 431 | 1(ref) | 1(ref) |
Any VT>10y ago (≤78 y#) | 31 | 14 | 2.4(1.2-4.5) | 3.0(1.5-6.1) |
Any VT>10y ago (>78 y#) | 28 | 11 | 2.7(1.3-5.6) | 2.4(1.1-5.2) |
Any VT 10-30y ago (≤ 78y#)& | 10 | 5 | 2.2(0.7-6.3) | 3.3(1.1-10.1) |
Any VT 10-30y ago (>78y#)& | 18 | 6 | 3.2(1.3-8.2) | 2.8(1.1-7.5) |
Any VT >30y ago (≤ 78y#)& | 19 | 8 | 2.6(1.1-5.9) | 2.8(1.1-7.0) |
Any VT >30y ago (> 78y#)& | 8 | 4 | 2.2(0.6-7.2) | 1.3(0.3-4.8) |
Conclusions: A remote history of VT is associated with the risk of VT in the elderly.
To cite this abstract in AMA style:
Wang H, R Rosendaal F, Cushman M, van Hylckama Vlieg A. Remote History of Venous Thrombosis and the Risk of Venous Thrombosis beyond the Age of 70 Years [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/remote-history-of-venous-thrombosis-and-the-risk-of-venous-thrombosis-beyond-the-age-of-70-years/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/remote-history-of-venous-thrombosis-and-the-risk-of-venous-thrombosis-beyond-the-age-of-70-years/