ISTH Congress Abstracts

Official abstracts site for the ISTH Congress

MENU 
  • Home
  • Congress Archive
    • ISTH 2022 Congress
    • ISTH 2021 Congress
    • ISTH 2020 Congress
  • Resources
  • Search

Retinal Vein Thrombosis and the Association with Inherited Thrombophilia, Cardiovascular Risk Factors and the Risk of Occult Cancer. a Prospective Study

D. Tormene1, G. Turatti1, C. Simion1, M. Marobin2, S. Gavasso1, E. Campello1, P. Simioni1

1University of Padova, Department of Medicine. Thrombotic and Hemorragic Disease Unit, Padova, Italy, 2University of Padova, Padova, Italy

Abstract Number: PB2332

Meeting: ISTH 2020 Congress

Theme: Venous Thromboembolism and Cardioembolism » VTE Epidemiology

Background: Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopaty. For this type of thrombosis the correlation with thrombophilic conditions, cardiovascular risk factors and the risk of the future development of cancer is still debated.

Aims: To evaluate the association between RVO and inherited thrombophilia or the common cardiovascular risk factors. To investigate the relationship between RVO and the risk of future development of cancer.

Methods: In this prospective study we enrolled a total of 145 subjects at their first event of RVO. Sixty-six healthy subjects who did not present with a history of thromboembolic events acted as the controls. A total of 1376 and 384 patient observation-years were considered in cases and controls, respectively.

Results: Sixteen subjects in the group of cases and six in the controls were identified as carriers of thrombophilia with a prevalence of 12.4% (95 % CI 7 to 18) and 10% (96% CI 3.7 to 20.5) respectively[ RR 1.2 (95%CI 0.5 to 3)].
One hundred and seven subjects in the group of cases and 38 in the controls presented with cardiovascular risk factor with a prevalence of 73% (95 % CI 66 to 81) and 58% (96% CI 44 to 70) respectively [RR 1.2 (95%CI 0.9 to 1.5)].
During the observation nineteen tumors developed in the group of cases (13%) as compared to four in the controls (6%). Overall, annual incidences of cancer were 1.4% (95% CI, 0.8 to 2.2) in cases and 1.05% ( 95% CI 0.3 to 2.7) in controls, respectively (RR, 1.3 [95% CI 0.5 to 4]).

Conclusions: Inherited thrombophilia is not associated with RVO while cardiovascular risk factor are weakly associated. RVO does not seem to be a marker for occult cancer.

To cite this abstract in AMA style:

Tormene D, Turatti G, Simion C, Marobin M, Gavasso S, Campello E, Simioni P. Retinal Vein Thrombosis and the Association with Inherited Thrombophilia, Cardiovascular Risk Factors and the Risk of Occult Cancer. a Prospective Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/retinal-vein-thrombosis-and-the-association-with-inherited-thrombophilia-cardiovascular-risk-factors-and-the-risk-of-occult-cancer-a-prospective-study/. Accessed October 1, 2023.

« Back to ISTH 2020 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/retinal-vein-thrombosis-and-the-association-with-inherited-thrombophilia-cardiovascular-risk-factors-and-the-risk-of-occult-cancer-a-prospective-study/

Simple Search

Supported By:

Takeda logo

ISTH 2022 Congress site

Visit the official web site for the ISTH 2022 Virtual Congress ยป

  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2023 John Wiley & Sons, Inc. All Rights Reserved.
Wiley