Abstract Number: PB2312
Meeting: ISTH 2020 Congress
Background: Thalassemia is an inherited red blood cell disorder characterized by reduced or absent production of the globin chain. Thromboembolic events are one of complications that may lead to morbidity and mortality of thalassemia patients. The prevalence of thromboembolic events in Thai patients with thalassemia has not been well described.
Aims: This study aimed to determine the prevalence and risk factors of thromboembolic events in patients with thalassemia.
Methods: This was a single center, cross-sectional study. Data were retrieved from Chiang Mai Thalassemia Registry between 2014 to 2019. We included all adult patients (age 15 years old or older) who were diagnosed with thalassemia, using a high-performance liquid chromatography (HPLC) methods. We collected data regarding to age, sex, type of thalassemia, transfusion requirement, cirrhosis, cardiomyopathy and basic laboratories. The primary outcome was the prevalence of objectively confirmed arterial or venous thrombosis.
Results: There were 543 thalassemia patients included in the study. The median age was 33 years (interquartile range 24-49 years) and 42.1% were males. Of these, 200 (36.9%) patients were transfusion dependent and 343 (63.2%) patients were transfusion independent. Splenectomy was performed in 38.9% of patients in this cohort. All of splenectomized patients had received aspirin. Thromboembolic events were observed in 29 patients, which translated into the prevalence of 5.3% (95% confidence interval [CI] 3.6% to 7.6%). Of these, 44.8% were arterial thrombosis and 55.2% were venous thrombosis. The sites of thrombosis are demonstrated in figure 1. The univariable analysis revealed that, older age (odds ratio [OR] 1.02, 95% CI 1.01-1.04, p = 0.049) and cirrhosis (OR 6.96, 95% CI 2.40-20.17, p< 0.001) were associated with thrombosis.
Conclusions: Thromboembolic complication was not uncommon in Thai thalassemia patients. Older age and liver were associated with higher risk of thrombosis.
To cite this abstract in AMA style:Hantrakun N, Kunlayawutipong T, Norasetthada L, Tantiworawit A, Rattaritamrong E, Rattanathammethee T, Huntrakool S, Piriyakhuntorn P, Chai-Adisaksopha C. Risk Factors of Thrombotic Complications in Thai Thalassemia Patients [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/risk-factors-of-thrombotic-complications-in-thai-thalassemia-patients/. Accessed October 1, 2023.
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