Abstract Number: PB2320
Meeting: ISTH 2020 Congress
Background: Although long-term complications of venous thromboembolism (VTE) (e.g.post-thrombotic syndrome) are known to hamper functional activities and impair quality of life, it remains unclear whether VTE is associated with subsequent risk of permanent work-related disability.
Aims: To investigate whether incident VTE is associated with subsequent work-related disability in the general population.
Methods: Using medical and administrative databases, a Danish nationwide cohort of 41,928 patients < 65 years with incident VTE during 1995-2016 was established. An age,-sex,-and calendar-year-matched comparison cohort was identified from the general Danish population
< 65 years (n=209,640). Incident VTE was ascertained at study inclusion with permanent work-related disability as study outcome. Cox-regression models were used to compute hazard ratios (HRs) with 95% confidence intervals (CIs) for disability in analyses stratified by sex and age-group (25-39, 40-54, 55-64 years) and adjusted for comorbidities (history of cancer, CHD, diabetes, stroke, obesity and COPD).
Results: 41,928 subjects with incident were included. Of these 3,893 were granted a permanent work-related disability pension (incidence rate=13.0 per 1,000 person-years). Subjects with VTE had a 3-fold (HR 2.90, 95%CI: 2.79-3.02) higher risk of subsequent disability pension than those without VTE. Adjustment for comorbidities had a modest impact on the risk estimate
(HR 2.47, 95% CI: 2.37-2.58). The risk of disability pension decreased slightly by age groups
(HR 2.96, 95% CI: 2.68-3.26 in the youngest to HR 2.19, 95% CI: 2.02-2.38 in the oldest). The risk of disability was somewhat higher in men versus women (HR 2.67, 95% CI: 2.50-2.84, vs. HR 2.32, 95% CI: 2.18-2.46), especially in younger men (HR 3.66, 95% CI: 3.12-4.30).
Conclusions: Our findings clearly showed that incident VTE is associated with subsequent permanent work-related disability pension, independent of comorbidities such as cancer and other cardiovascular diseases. The indirect costs and social consequences associated with lost work-ability may add to the economic burden of VTE.
To cite this abstract in AMA style:Jorgensen H, Horváth-Puhó E, Laugesen K, Braekkan S, Hansen J-, Sørensen HT. Risk of Receiving a Permanent Work-Related Disability Pension After Incident Venous Thromboembolism [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/risk-of-receiving-a-permanent-work-related-disability-pension-after-incident-venous-thromboembolism/. Accessed September 21, 2023.
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