Abstract Number: PB2339
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Epidemiology
Background: Several lifestyle risk factors have been associated with the risk of VT in young and middle-aged population.
Aims: To investigate whether lifestyle factors (BMI, body height, body weight, smoking, and alcohol use) are associated with the risk of VT in elderly and to assess the joint effect with genetic risk factors for VT (i.e, the factor V Leiden (FVL) or prothrombin 20210A (PT20210) mutation).
Methods: Analyses were performed in the AT-AGE study, a multi-center case-control study performed in Vermont, USA and Leiden, NL, comprising of 401 cases with a first VT and 431 control subjects, all aged >70 years. To assess the risk of VT, odds ratios (OR) with 95% confidence intervals were calculated, after adjustment for potential confounders (age, sex, and study center). Weight and height were divided into quartiles based on the distribution in the controls.
Results: BMI as well as height and weight separately were positively associated with the risk of VT albeit risk estimated were modest. ORs were 1.3 (0.9-1.9) for BMI>30 compared with BMI< 25 kg/m2 and 1.5 (1.0-2.4) and 2.2 (1.2-3.9) for weight and height in the highest compared with the lowest quartile, respectively. No association with VT was observed for smoking or alcohol use (table 1). Risks were similar for DVT and PE separately. The risk of VT was most pronounced in the presence of multiple risk factors, i.e, the OR was ~3 in individuals who were overweight or had a height or weight in the highest quartile in the presence of FVL or PT20210A (table 2).
Conclusions: In the elderly, BMI as well as body weight and height separately were associated with the risk of VT, while smoking and alcohol use were not. The risk of VT was highest in the presence of FVL or PT20210A.
| Risk factor | All VT OR*(95%CI) | DVT only OR*(95%CI) | PE±DVT OR*(95%CI) |
| BMI(kg/m2) | |||
| normal | 1(ref) | 1(ref) | 1(ref) |
| obese | 1.3(0.9-1.9) | 1.5(0.9-2.4) | 1.2(0.7-1.9) |
| Smoking status | |||
| former+never | 1(ref) | 1(ref) | 1(ref) |
| current | 0.8(0.5-1.2) | 1.0(0.5-1.7) | 0.7(0.4-1.1) |
| Alcohol intake status | |||
| not current | 1(ref) | 1(ref) | 1(ref) |
| current | 1.0(0.7-1.4) | 1.1(0.8-1.7) | 1.0(0.7-1.4) |
[The risk of venous thrombosis(all VT, DVT only and PE±DVT) associated with lifestyle factors]
| Risk factor | FVL/FII20210A | Patients | Controls | All VT OR* |
| BMI(kg/m2) | ||||
| normal | no | 114 | 145 | 1(ref) |
| overweight | yes | 24 | 12 | 2.9(1.3-6.3) |
| Height | ||||
| no | 150 | 189 | 1(ref) | |
| ≥P50 | yes | 23 | 13 | 3.1(1.4-6.7) |
| Weight | ||||
| no | 150 | 196 | 1(ref) | |
| ≥P50 | yes | 23 | 11 | 3.1(1.4-6.8) |
[Combined effect of some exposures with the factor V Leiden(FVL) or prothrombin(FII)20210A mutations the risk of venous thrombosis]
To cite this abstract in AMA style:
Wang H, Cushman M, Rosendaal F, van Hylckama Vlieg A. Risk of Venous Thrombosis in the Elderly: Lifestyle and its Joint Effect with Factor V Leiden and Prothrombin 20210A [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/risk-of-venous-thrombosis-in-the-elderly-lifestyle-and-its-joint-effect-with-factor-v-leiden-and-prothrombin-20210a/. Accessed October 2, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/risk-of-venous-thrombosis-in-the-elderly-lifestyle-and-its-joint-effect-with-factor-v-leiden-and-prothrombin-20210a/