Background: It has been reported that mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-lymphocyte ratio (MPVLR), and neutrophil-to-lymphocyte ratio (NLR) may play a role in the diagnosis of venous thromboembolic disease (VTE). These parameters are easy to obtain from a complete blood count.

Aims: Analyze the association between these parameters and the recurrence of VTE.

Methods: An observational, retrospective study was conducted. Inclusion criteria: Patients with a first venous thromboembolic event (deep vein thrombosis and/or pulmonary thromboembolism), who had a complete blood count within the first 7 days after the event.
The values of MPV, PLR, MPVLR, and NLR that the patients had at the time of diagnosis were analyzed.
The patients were divided according to whether they had recurred or not after the first event. The association between the previously named parameters and the recurrence was analyzed.

Results: 71 patients were included. MPV (8.5 vs. 9 fl, p = 0.43), PLR (147 vs. 216, p = 0.22), MPVLR (0.0048 vs. 0.0076, p = 0.094) and NLR (3.73 vs. 4, 15, p = 0.66) had higher values in the recurrence group, although this difference was not statistically significant. Given the result a ROC curve analysis of MPVLR for predicting recurrence in VTE was performed which found a cut-off value of 0.0047 for MPVLR, an area under curve of (0.688, 0.51-0.87), p = 0.049, with a sensitivity of 64% and specificity of 62%.In the provoked VTE event group of patients, MPVLR was higher in the recurrence group (0.0053 vs 0.0083, p = 0.058) and in the cancer associated thrombosis (CAT) group the difference in the MPVLR was statistically significant (0.006 vs 0.011, p = 0.013).

Conclusions: MPVLR could a potential marker for recurrence in VTE, especially in the CAT group. Larger and prospective studies about the subject are needed.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/rmean-platelet-volume-to-lymphocyte-ratio-and-vte-recurrence/