Abstract Number: PB2411
Meeting: ISTH 2020 Congress
Background: Residual vascular pulmonary obstruction (RVPO) after pulmonary embolism (PE) has been associated with recurrent venous thromboembolism (VTE) after 2-3 year follow-up. However, there is no standardized definition of RPVO and its predictive role on recurrent VTE requires confirmation.
Aims: To determine whether RPVO is associated with recurrent VTE after 10 years.
Methods: Consecutive patients were evaluated 6 to 12 months after objectively diagnosed PE at the Thrombosis Center of ASST Sette Laghi (Varese, Italy) and underwent lung perfusion scan between 2004 and 2008 to detect RPVO, as part of a previously published study. In 2019 patient electronic clinical records were searched or, if missing, patients were contacted by telephone, to detected objectively diagnosed recurrent VTE.
Results: 112 patients were included in the study. At the time of PE diagnosis, the mean age was 62.5 years (DS 16.3) and the proportion of females/males were 58/42%. PE was unprovoked in 62 patients (55.4%) and DVT was diagnosed in 72 patients (64.3%). As compared to diagnostic imaging, follow-up lung perfusion scan, performed after 12.9 months (DS 10.4), identified no change in 21 patients (19%), partial reperfusion in 25 (22%) and complete reperfusion in 66 (59%). Older age and unprovoked PE were more frequent in patients with RPVO as compared to those without. During a mean follow-up of 117.1 months (DS 59.6), 31 patients (27.7%) were diagnosed with recurrent VTE (23 PE, 8 isolated deep vein thrombosis). Recurrent VTE occurred in 26.1% of patients with RPVO as compared to 28.8% without RPVO (p=ns).
Conclusions: In this study, during 10-year follow-up, RPVO was not associated with recurrent VTE. Larger studies are needed to confirm the predictive role of RPVO, by using a standardized definitio.
To cite this abstract in AMA style:Donadini MP, Boniardi F, Dentali F, Ageno W. Role of Residual Pulmonary Vascular Obstruction on the Risk of Long-Term Recurrence of Venous Thromboembolism After Pulmonary Embolism: A Cohort Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/role-of-residual-pulmonary-vascular-obstruction-on-the-risk-of-long-term-recurrence-of-venous-thromboembolism-after-pulmonary-embolism-a-cohort-study/. Accessed September 27, 2023.
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