Abstract Number: PB2575
Meeting: ISTH 2020 Congress
Background: Venous Thromboembolic Disease (VTD) is the leading cause of maternal mortality in the developed countries. The absolute risk of VTD in pregnancy is low so the risk needs to be stratified to justify pharmacological thromboprophylaxis1.Caesarean section (CS) causes endothelial damage 2,3, it has five to nine times higher thrombosis risk than vaginal delivery (VD) 4,5,6,7.TGP could identify CS patients who would have benefit from thromboprophylaxis.
Aims: To determine and compare TGP in VD vs CS.
To evaluate TGP as an additional risk marker to guide thromboprophylaxis in CS.
Methods: We performed a cross-sectional observational analytical study at Pereira Rossell Hospital (Montevideo, Uruguay), between October 2018 and August 2019. Individual consent was taken. It was approved by institutional ethics committee.TGP was measured in the automated BCS® XP coagulation analyzer.
Results: We studied 220 pregnant women, 70 CS and 150 VD. Characteristics of pregnancy and type of delivery are described in table 1.Women age, BMI and results of TGP are described in table 2. No differences were observed between maternal age and BMI in the two groups. The AUC2 ETP (ME) was statistically lower in group VD, p value < 0.001. The ETPB AUC2 CAL was statistically lower in group VD, p value p = 0.010.
Conclusions: TGP was statistically higher in patients with CS. Caesarean section was identified as a thrombin generating event associated with the greater endothelial damage it produces. Therefore, it could be an interesting biomarker for identify patients with a higher risk of VTD.
To cite this abstract in AMA style:Perez De Palleja M, Turcatti P, Olivera A, Raposo D, Canessa C, Guillermo C. Role of Thrombin Generation Potential (TGP) in Cesarean Sections and Vaginal Deliveries Puerperium to Guide Thromboprophylaxis. Preliminary Results [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/role-of-thrombin-generation-potential-tgp-in-cesarean-sections-and-vaginal-deliveries-puerperium-to-guide-thromboprophylaxis-preliminary-results/. Accessed October 19, 2021.
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