Rotational Thromboelastometry (ROTEM) Profiling of COVID–19 Patients

M. Mitrovic^1,2, N. Sabljic¹, Z. Svetkovic^3,2, N. Pantic¹, Z. Bukumiric⁴, N. Savic⁵, B. Milenkovic^6,2, M. Virijevic^1,2, Z. Pravdic¹, N. Suvajdzic^1,2, J. Fareed⁷, D. Antic^1,2

¹Clinic of Hematology, Clinical Center of Serbia, Belgrade, Serbia, ²Faculty of Medicine, University of Belgrade, Belgrade, Serbia, ³Clinical Hospital Center Zemun, Belgrade, Serbia, ⁴Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia, ⁵Clinic of Vascular Surgery, Clinical Center of Serbia, Belgrade, Serbia, ⁶Clinic of Pulmology, Clinical Center of Serbia, Belgrade, Serbia, ⁷Departments of Pathology and Pharmacology, Loyola University Center, Maywood, United States

Abstract Number: PB0233

Meeting: ISTH 2021 Congress

Theme: COVID and Coagulation » COVID and Coagulation, Clinical

Background: Administration of a standard-dose thromboprophylaxis in all hospitalized Coronavirus disease (COVID-19) patients is recommended. However, despite thromboprophylaxis, frequent thrombotic complications are diagnosed. Rotational thromboelastometry (ROTEM) is a method to access hypercoagulable state in whole blood from these patients.

Aims: To analyze ROTEM parameters during the entire clinical COVID-19 stages including mild, moderate and critical phases and to assess the extent of hypercoagulablity by profiling ROTEM patterns.

Methods: We evaluated coagulation abnormalities via traditional tests and ROTEM profile in a group of 94 patients with confirmed SARS-CoV-2 infection with different severity of pneumonia (34 moderate, 25 severe, 35 critical). Shorter than normal clotting time (CT) and higher than normal maximum clot firmness (MCF) in extrinsic rotational thromboelastometry (EXTEM) and fibrinogen rotational thromboelastometry (FIBTEM), shorter than normal EXTEM clot formation time (CFT), and higher than normal α-angle were identified as markers of hypercoagulable state.

Results: At least one hypercoagulable ROTEM parameter had 62 (66%) patients. Increment in the number of patients with ≥ 2 hypercoagulable parameters, higher EXTEM (P = .0001), FIBTEM MCF (P=0.0001) and maximum lysis decrement (P=0.002) with increment in disease severity was observed (P=0.0001). Significant positive correlations between IL6 and CT EXTEM (P=0.003), MCF EXTEM (P=0.033), MCF FIBTEM (P=0.01), and negative with ML EXTEM (P=0.006) were seen.

Conclusions: These findings confirm that a hypercoagulable ROTEM profile characterized by clot formation acceleration, high clot strength, and reduced fibrinolysis was more frequent in advanced disease groups and patients with elevated IL6. These results underscore the need for different thromboprophylactic approaches for different severity groups.

To cite this abstract in AMA style:

Mitrovic M, Sabljic N, Svetkovic Z, Pantic N, Bukumiric Z, Savic N, Milenkovic B, Virijevic M, Pravdic Z, Suvajdzic N, Fareed J, Antic D. Rotational Thromboelastometry (ROTEM) Profiling of COVID–19 Patients [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/rotational-thromboelastometry-rotem-profiling-of-covid-19-patients/. Accessed May 19, 2022.

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