Abstract Number: PB1057
Meeting: ISTH 2020 Congress
Background: Reports on patients’ satisfaction and preferred characteristics for treatments would be worthwhile when choosing an optimal treatment reflecting the patient’s perspective.
Aims: This was to describe the satisfaction and preference of hemophilia A patients/parents for the treatments in Korea.
Methods: This study was approved by National Institute for Bioethics Policy Review Board and conducted from Apr2018 to Sep2019 in 6 hospitals, representative for hemophilia treatments in Korea. Hemophilia A patients aged≥16years or parents of pediatric patients, who had used factor VIII concentrates for ≥1month were enrolled, after obtaining informed consent. We used Treatment Satisfaction Questionnaire For Medication(TSQM), consisted of 4 domains with each score(0-100) indicating the higher the better. For preference, we performed discrete-choice experiment with 10 series of 2 hypothetical treatment options created from D-efficient block design, which varied across 5 attributes(Fig 2). Multivariable linear regressions, count analysis, and conditional logistic regressions were performed. Positive Best-Worst(BW) score indicates predominantly “best” choice and higher part-worth utility indicates more preference.
Results: Of total 505 patients(aged mean31.5, treated for average102months), 87.7% were severe, 53.5% treated as prophylaxis way, 80% used two connected vials while only 6.3% used prefilled dual chamber(PDC) syringe, and 52.3% experienced bleedings. Average TSQM were 64.6 in effectiveness, 97.9 in side effects, 57.1 in convenience, and 66.8 in global satisfaction. Type of device, number of vials, and administration frequency were associated with treatment satisfaction(Fig.1). Concerning preference,＜2times/month administration2(0.39BW) and PDC(0.22BW) were strongly preferred whereas ≥2times/month administration(-0.42BW) was mostly rejected. Lesser frequency and PDC showed higher part-worth utility(Fig. 2).
Conclusions: Hemophilia A patients in Korea were insufficiently satisfied with their treatments. Since patients reported the worst satisfaction in the convenience domain amongst 4 domains and gave a preference to simpler characteristics of treatment such as lesser frequency of administration and easier device type, more convenient treatment strategies are primarily required.
[Figure 1. Risk factors for TSQM]
To cite this abstract in AMA style:Yoo KY, Hwang TJ, Park YS, Kim YJ, Park HR, Shin JS, Lee HJ, Nam CM, Sun JY. Satisfaction and Preference of Hemophilia A Patients and Parents for the Treatments in Korea; Results from a Multicentered, Cross-sectional, Observational Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/satisfaction-and-preference-of-hemophilia-a-patients-and-parents-for-the-treatments-in-korea-results-from-a-multicentered-cross-sectional-observational-study/. Accessed September 22, 2023.
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