Abstract Number: PO115
Meeting: ISTH 2021 Congress
Background: Seasonal variations of cardiovascular complications is signed by different authors (Turin T. C. et al., 2008; Khan F. A. et al., 2005). The activation of clotting is rapid protective reaction to vessel damage. At the same time, the studies which present correlations of platelets aggregation with seasonality, and, also, describe clinical risk of vascular complications are limited.
Aims: To analyze the seasonal changes of platelet aggregation indexes, and, also, risk of thrombotic complications at patients with stable angina in emergency care clinic.
Methods: The study included 939 people (male – 507, female – 432, average age – 42.1±8.9 years). The analysis of platelet aggregation was carried out on the analyzer of platelet aggregation “BIOLA” 230LA by J. Born method.
Results: It is set that the highest risk of thrombotic complications has been on February and March, where contribution of patients with thromboembolism are 20,9% (p=0,001). Probability of thromboembolism in the 1st quarter of the year among surgical patients in the postoperative period is set as 29,9% (p<0,005). At the patients with thrombotic complications are estimated the higher level of spontaneous (p<0,05), ADP-induced aggregation (p<0,05), and the speed of induced aggregation in compare with healthy volunteers (p<0,05). Due to seasonal changes the 63,0% patients have higher level of ADP-induced aggregation than grouping median in the 1-st quarter of year, and the lowest risk due to the aggregation parameters are set at the 4th quarter.
Conclusions: In patients with stable angina were proved seasonal variations of thrombotic complications: the highest risk of thrombosis occurs in February and March due to increased level of spontaneous and ADP-induced platelet aggregation.
To cite this abstract in AMA style:Shorikova D, Shorikov E, Shorikov P. Seasonal Changes of Platelet Aggregation Indexes at the Patients with Stable Angina [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/seasonal-changes-of-platelet-aggregation-indexes-at-the-patients-with-stable-angina/. Accessed May 19, 2022.
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