Abstract Number: PB0140
Meeting: ISTH 2020 Congress
Theme: Coagulation and Natural Anticoagulants » Animal Models in Thrombosis and Hemostasis
Background: The incidence, risk factors, and prognosis of thrombotic disorders differ among men and women. However, if the use of sex-matched animal models is not enforced in preclinical stages of research, it might lead to sex bias in proceeding clinical trials.
Aims: We aimed to systematically review the gender of animal models used in thrombosis research in the past 2 years.
Methods: We searched PubMed using search terms “thrombosis” AND “animal”. Articles published in the past 2 years (between January 2018 and December 2019) and reporting original data from in-vivo experiments were included in our analysis. Each article was independently reviewed for types and sexes of the animal models used and, if study samples were sex-matched.
Results: Of 1052 articles screened, our review included 308 studies for analysis. The kappa interrater agreement for study inclusion before resolution was 0.92. Among included studies, sex of the animals used was not reported in 30.5%; males were exclusively used in 49.7%; females were exclusively used in 9.1%; and both sexes were used in 10.7%. Sex matching of animals was reported in 54.5% of studies that included both sexes. A total of 11 animal models were employed; mice were used in 54.9% of studies, followed by rats (25.1%) and pigs (7%).
Conclusions: Although there are different risk factors and mechanisms involving thrombus formation between males and females, a predominant number of studies in the past 2 years employed only male animal models. In order to ensure gender balance and improve the quality of in-vivo thrombosis research, journals and funding bodies need to emphasize the report of gender in animal models used.
To cite this abstract in AMA style:
Tieu PT, Afraz S, Dietrich N, Lott J, Slapnicar C, Thai N, Wang V, Chan AKC, Matino D. Sex Bias in Animal Models of Thrombosis Research [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/sex-bias-in-animal-models-of-thrombosis-research/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/sex-bias-in-animal-models-of-thrombosis-research/