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Significance of Macrophage Migration Inhibitory Factor and Toll-Like Receptor 4as Predictive Factors of Sepsis in Shock Patients

S.-H. Choi1, S.-J. Park1, K.-W. Kim2, Y.-D. Cho1

1Korea University Guro Hospital, Seoul, Korea, Republic of, 2Injae university Ilsan Baek hospital, Goyang, Korea, Republic of

Abstract Number: PB1994

Meeting: ISTH 2020 Congress

Theme: Vascular Biology » Inflammation and Sepsis

Background: Many patients die from sepsis and multiple organ failure, even though proper management in shock patients. Early prediction of sepsis in shock patients is important and used in various ways, such as c-reactive protein (CRP), white blood cell (WBC) and procalcitonin (PCT), but they have some problems. Recently, toll-like receptor (TLR), macrophage migration inhibitory factor (MIF) have emerged as predictive factors.

Aims: Our study aims to explore the significance of TLR, MIF as predictors of sepsis in shock patients.

Methods: This study were conducted on prospective observational study patients who visited an emergency medical center in a university hospital from March 1, 2019 to December 31, 2019 and were intended for shock patients aged 18 or older. We measured WBC, CRP, PCT, MIF, TLR4, TNF-α, Interleukin-6 (IL-6), and lactic acid with serum taken from the patient´s blood. The definition of sepsis was defined as being part of SIRS criteria with infections within a week.

Results: 153 hemorrhagic shock patients were registered in emergency department, 44 of whom had sepsis within a week. The PCT, WBC, TNF-α, IL-6 did not differ in the comparison between sepsis and non-sepsis patients, while the CRP was somewhat high in sepsis patients (133.95±16.24mg/L > 60.46±3,57mg/L). However, MIF was significantly elevated in sepsis (2633±710pg/mL) to non-sepsis group (1460±680pg/mL). and also TLR4 was elevated in sepsis (16.27±2.05) to non-sepsis group (7.78±0.59). There was no correlation between MIF, TLR4 and lactic acid, which is the diagnostic criteria of shock.

Conclusions: It is believed that MIF amd TLR4 may be used as predictors of sepsis in shock patients. However, more research on the occurrence of MIF and TLR4 are thought to be necessary.

To cite this abstract in AMA style:

Choi S-, Park S-, Kim K-, Cho Y-. Significance of Macrophage Migration Inhibitory Factor and Toll-Like Receptor 4as Predictive Factors of Sepsis in Shock Patients [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/significance-of-macrophage-migration-inhibitory-factor-and-toll-like-receptor-4as-predictive-factors-of-sepsis-in-shock-patients/. Accessed September 27, 2023.

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