Background: Many patients die from sepsis and multiple organ failure, even though proper management in hemorrhagic shock patients. Early diagnosis of sepsis in hemorrhagic shock patients is important and used in various ways, such as CRP and WBC, procalcitonin (PCT), but they have some problems. Recently, macrophage migration inhibitory factor (MIF) have emerged as predictive factors.

Aims: Our study aims to explore the significance of MIF as a predictor of sepsis in hemorrhagic shock patients.

Methods: This study was conducted on prospective observational study patients who visited an emergency medical center in a university hospital from March 1, 2019 to December 31, 2019 and were intended for hemorrhagic shock patients aged 15 or older. We measured WBC, CRP, PCT, MIF, TNF-α, Interleukin-6 (IL-6), and lactic acid with serum taken from the patient´s blood. The definition of sepsis was defined as being part of SIRS criteria with infections within a week.

Results: 180 hemorrhagic shock patients were registered in emergency department, 28 of whom had sepsis within a week. The CRP, WBC, TNF-α, IL-6 did not differ in the comparison between sepsis and non-sepsis patients, while the PCT was somewhat high in sepsis patients (0.24±0.1ng/mL > 0.18±0.07ng/mL), but with had no statistical significance. However, MIF was significantly elevated in sepsis (2633±710pg/mL) to non-sepsis group (1460±680pg/mL). There was no correlation between MIF and lactic acid, which is the diagnostic criteria of shock.

Conclusions: It is believed that MIF may be used as a measure of sepsis in hemorrhagic shock patients. However, more research on the occurrence of MIF is thought to be necessary.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/significance-of-macrophage-migration-inhibitory-factor-for-sepsis-in-hemorrhagic-shock-patients/