Abstract Number: PB0779
Meeting: ISTH 2021 Congress
Background: To standartize the collection and quantify bleeding symptoms, in 2009 Bowman and colleagues developed PBQ, but its role in identifying patients reauiring futher laboratory evaluation is poorly understood.
Aims: To access specificity and sensitivity of PBQ in identifying the laboratory cause of bleeding in children.
Methods: We have performed a retrospective analysis of medical records of 346 patients (0-17 years), who attended Outpatient Consultative Clinic of our tertiary care Centre because of excessive bleeding symptoms excepting thrombocytopenia from 2017 to 2019. Translated PBQ forms were filled with a doctor, and then all the patients had a laboratory evaluation to verify a bleeding disorder (CBC, PT, APPT, TT, Fibrinogen, vWF:RCo, LTA with ristocetin, collagen, adrenalin, ADP, platelet cytofluorometry). Specificity and sensitivity, of PBQ points in evaluation of any test alteration were calculated using ROC-analysis (XLSTAT, Addinsoft).
There was a variability in the scores obtained between children in groups; it was also noted for different children with the same diagnosis (pic.1). If a positive bleeding score was defined as ≥2; the sensitivity of the method was 98%, the specificity was 12%. The best ratio of sensitivity and specificity (69% and 79%, respectively) was achieved when the positive bleeding score was ≥4 points (pic 2).
Conclusions: In our cohort, using local screening test battery, the majority of patients with PBQ=2 had no laboratory confirmation, but if PBQ≥4 was used as a cutoff, a substantial part of mild bleeding disorders could be potentially misdiagnosed. We found PBQ was handy and useful to collect and standardize bleeding symptoms, but can’t be used as a tool, which could alter our decision to test or not to test.
Reference: Bowman M., et al. JTH;2009;7(8):1418–1421.
To cite this abstract in AMA style:Yafoshkina T, Florinskiy D, Voronin K, Polokhov D, Poletaev A, Seregina E, Fedorova D, Zharkov P. Specificity and Sensitivity of Pediatric Bleeding Questionnaire (PBQ) in Identifying Patients Requiring further Laboratory Evaluation [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/specificity-and-sensitivity-of-pediatric-bleeding-questionnaire-pbq-in-identifying-patients-requiring-further-laboratory-evaluation/. Accessed December 11, 2023.
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