Abstract Number: PO106
Meeting: ISTH 2021 Congress
Background: Large mature or immature lipid core (atheroma) within a thick connective tissue containing of macrophages, smooth muscle cells, lipid laden- cells and a lot of fibrous- derived extracellular matrix with a low probability of calcification, is called stable fibroatheromatic plaque. The management of stable fibroatheromatic plaque reduces the risk of ischemic stroke and its related deaths. Management options are invasive and include carotid endarterectomy and carotid artery stenting.
Aims: In this study, we developed an experimental electrohydraulic shock wave generator (0–20 kv), and investigated its effectiveness on stable fibroatheromatic plaque regression in the golden Syrian hamster common carotid artery.
Methods: Stable fibroatheromatic plaque with severe stenosis (>80%) was induced at the right common carotid artery of golden Syrian hamsters. The animals treated by repeated electrohydraulic focused shock waves (V= 20 Kv, F= 0.3 Hz, Impulses= 120) accompanied by PESDA microbubbles (100 μl/kg, 2–5×105 bubbles/ml) and high- dose atorvastatin (5 mg/kg/day) administration. Blood volume flow and blood mean velocity were measured by color Doppler ultrasonography at the stenotic region. Moreover, wall mean thickness and percentage of luminal cross-sectional area of stenosis were measured by B-mode ultrasound and histology.
Results: Results from histopathology, color Doppler and B-mode ultrasonography showed a significant reduction in the mean value for blood mean velocity, wall mean thickness and the percentage of luminal cross-sectional area of stenosis and a significant increase in the mean value for blood volume flow in the treatment group compared with the other groups (P < 0.05).
Conclusions: Enhanced inertial cavitation- mediated sonoporation effect of shock waves, induced by collapsed microbubbles accompanied by enhanced lipophilic and pleiotropic effects of atorvastatin- induced by high-dose administration, can cause to reduce the lipid- laden cells, macrophages in the plaque lipid core and significantly dilate the luminal cross-sectional area of stenosis and regress the thick- cap fibroatheromatic plaque.
To cite this abstract in AMA style:Mehrad H, Farhoudi M. Stable Fibroatheromatic Plaque Regression Using High-dose Atorvastatin-loaded PESDA Microbubbles-mediated Extracorporeal Shock Wave Sonoporation Therapy [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/stable-fibroatheromatic-plaque-regression-using-high-dose-atorvastatin-loaded-pesda-microbubbles-mediated-extracorporeal-shock-wave-sonoporation-therapy/. Accessed November 29, 2021.
« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/stable-fibroatheromatic-plaque-regression-using-high-dose-atorvastatin-loaded-pesda-microbubbles-mediated-extracorporeal-shock-wave-sonoporation-therapy/