Background: TLR7/8 are immune receptors expressed in megakaryocytes which detects single-stranded RNA viruses such as SARS-CoV-2. There is increasing evidence that in addition to raised platelet counts, severe infection with SARS-CoV-2 increases the risk of venous, arterial and microvascular coagulation. Aims: To determine if ssRNA viruses are capable of increasing thrombopoeisis through direct interaction with … Continue reading Stimulation of the ssRNA virus immune receptor, Toll-like receptor 7, on megakaryocytes increases thrombopoesis.
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