Background: the deficiency in coagulation inhibitors (protein C, S, Z, and anti-thrombin III) predispose to thrombosis , multiple and serious locations in young patients, its prevalence is 1/500,000 inhabitants.

Aims: clinical presentation of congenital thrombophilias in the university hospital center of Oran in Algeria

Methods: We identified all patients with congenital thrombophilia followed at the Hematology department of the University Hospital of Oran. We studied the history, hematematric parameters, as well as the balance sheet of thrombophilia with deficiencies in coagulation inhibitor (protein C, S and Anti-thrombin III)

Results: among the 12 patients; 09 female and 03 male, sex ratio 0.33, the average age is 32 years with extremes between 6 and 57 years. Half of the patients have an asymptomatic deficit discovered during family screening, 02 patients have a portal thrombosis, 02 have a pulmonary embolism, 1 patient has a thrombosis of the popliteal vein and another presenting a cerebrovascular accident, we did not note any abortion. Average hemoglobin is 12.5 g/dl (11-13), platelet count 230,000/mm3 (47000-404000), white blood cell count 5500/mm3 (1500-145000). The thrombophilia assessment found a protein S deficiency in 08 patients, the protein S level between 24 and 46% and 04 patients with a protein C deficiency (27-37%).

Conclusion(s): Female predominance of congenital thrombophilias, although some forms are asymptomatic. There are serious forms of these coagulation inhibitor deficiencies, such as pulmonary embolisms. The degree of the deficit is not predictive of thrombotic risk, but the existence of a chronic inflammatory state increases the incidence of thrombosis.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/studies-of-congenital-thrombophilia-experience-of-the-university-hospital-center-of-oran-in-algeria/