Abstract Number: PB0057
Meeting: ISTH 2020 Congress
Background: Every day, interest in the Arctic is increasing, more and more people are arriving in adverse climatic and geographical conditions of the Far North. Therefore, there is a need to study the adaptation of vascular endothelium to the conditions of the far north.
Aims: To assess the change in the concentration of endothelin in the sailors of the transarctic flight “TRANSARCTICA-2019”.
Methods: The subjects of the study were 33 sailors (29 men, 4 women) average age 39 years (range: 20-63). Sampling was carried out at zero point – Arkhangelsk N64°33′ E40°32′, and at a high point – island Hayes N80°34′ E57°41′. The parameters were determined gender, age, the concentration of endothelin-1 (determined by enzyme immunoassay). Statistics. The article was prepared as part of a study supported by a grant from the RFBR project No. 18-00-00814-COMFI (18-00-00478).
Results: The concentration of endothelin-1 in the crew of the transarctic flight TRANSARCTICA-2019 – Minimum concentration (pg / ml) – 0.814 – 2.321, The maximum concentration (pg / ml) 8.369-12.662, Mean value (M) (pg / ml) and standard deviation (SD) Mean value (M) (pg / ml) and standard deviation (SD).
M = 4. 79 SD = 2.10. Statistically significant differences were obtained in the average concentration of endothelin in sailors at the zero and high points in the population
(t = -3.6532, df = 31, p = 0.0009).
Conclusions: It was shown that under the conditions of a trans-latitudinal flight, the concentration of endothelin-1 increases. This may indicate the formation of a state of maladaptation of the vascular endothelium with a tendency to vasoconstriction in high latitudes. Further research is needed on changes in the parameters of endothelial dysfunction during adaptation to the climate of the Far North.
To cite this abstract in AMA style:Vorobyeva N, Melnichuk E, Beliakov E. Study of Fluctuations in the Endothelin Concentration of the Crew Trans-Latitude Journey Transarctica-2019 [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/study-of-fluctuations-in-the-endothelin-concentration-of-the-crew-trans-latitude-journey-transarctica-2019/. Accessed November 30, 2021.
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