Abstract Number: PB0069
Meeting: ISTH 2020 Congress
Theme: Arterial Thromboembolism » Cardiovascular Risk Factors
Background: Emerging evidences suggest physio-pathologic relationship between cardiovascular (CV) diseases and cancer. In fact, oxidative stress and inflammation play a leading role both in atherogenesis and cancer genesis.
Aims: We conducted a case-control study to evaluate the presence of endothelial dysfunction and early vascular disease in patients with cancer.
Methods: Patients with a first diagnosis of solid or hematologic cancer were consecutively enrolled (cases). Sex- and age-matched patients without history of cancer acted as controls. Exclusion criteria: previous venous or arterial thrombosis, ongoing anticoagulation, age >80 years, previous radio- or chemotherapy. Endothelial dysfunction was evaluated by ankle-brachial index (ABI) and intima-media thickness (IMT) or presence of carotid plaques by ultrasound. ABI ≤0.9 means presence of peripheral artery disease; carotid IMT was consider abnormal when > 0.9 mm.
Results: 64 cases (16 hematologic and 48 solid cancers; M/F 36/28; mean age 68 ± 9 years) and 70 matched- controls (M/F 38/32; mean age 64 ± 11 years) were enrolled. The CV risk profile (measured by American College of Cardiology/American Heart Association [ACC/AHA] score) was comparable between groups, as well as the proportion of patients taking antiplatelet drugs and statins. A significantly higher proportion of cases (n 62, 97%) showed carotid IMT compared to controls (n 50, 71%.; OR 12.8 [95%CI 2.8-57.3]). No difference in the proportion of abnormal ABI and presence of carotid plaque was detected. Interestingly, more cases with advanced solid cancer (n 22, 73%) had carotid plaque compared with cases with local solid tumors (n 6, 33%; OR 5.5 [95% CI 1.5-19.6]).
Conclusions: Patients with cancers, especially advanced, presented at diagnosis with endothelial dysfunction and asymptomatic vascular disease. This may be due to the inflammatory response towards the neoplasm and may led to a higher CV risk profile.
To cite this abstract in AMA style:
Borella E, Campello E, Spiezia L, Dalla Valle F, Poretto A, Turatti G, Marobin M, Simion C, Simioni P. Study of the Endothelial Dysfuncion in Patients with Cancer: Preliminary Results [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/study-of-the-endothelial-dysfuncion-in-patients-with-cancer-preliminary-results/. Accessed April 19, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/study-of-the-endothelial-dysfuncion-in-patients-with-cancer-preliminary-results/