Abstract Number: PB0484
Meeting: ISTH 2020 Congress
Background: Hemostasis is the set of mechanisms that aim to stop bleeding.
The coagulation tests are influenced by the delay between the sampling and their accomplishments. For this, it is recommended by most guidelines to carry out these tests within 4h after the sampling.
Aims: To determine the stability of the main hemostasis parameters at 6h of sampling.
Methods: Our study, which took place at CHTS Mustapha CHU on 40 apparently healthy subjects, evaluated the stability of TP, TCK, Fg, D-dimers, FVII and PC on citrated whole blood and on citrated plasma after less than 2 h, 4h and 6h sampling at 23 ° C.
Results: Conservation of whole blood up to 4 and 6 hours resulted in significant changes in TP and TCK, whereas < 25% of samples had a variation
> 10% which makes it possible to preserve the stability of the studied parameter.
Among the remaining parameters, only the FVII showed a significant difference after 6 h, and 30% of the samples had a variation> 10% having a percentage average of variation> 10%, which does not allow to maintain the stability.
In citrated plasma, only TP, TCK and Fg have significant differences after 4h and 6h, gold < 25% of the samples show a variation> 10.
Conclusions: TP, TCK, Fg, D-dimers and PC are stable up to 6 h in whole blood and in citrated plasma. The stability of FVII in whole blood is 4 h, and 6 h in citrated plasma.
To cite this abstract in AMA style:Hadjali-Saichi S, Guenounou-Guemmour K, Frigaa I. Study of the Stability of the Main Parameters of Hemostasis Over Six Hours [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/study-of-the-stability-of-the-main-parameters-of-hemostasis-over-six-hours/. Accessed November 30, 2021.
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