Abstract Number: PB0058
Meeting: ISTH 2020 Congress
Theme: Arterial Thromboembolism » Cardiovascular Risk Factors
Background: Interest in the Arctic territories and number of scientific expeditions is increasing. Therefore, there is a need to study the adaptive capabilities of the human hemostatic system in the North. One method that can evaluate hyper- and hypocoagulation conditions is the thrombin generation assay (TGA).
Aims: To evaluate the change in the TGA parameters of the crew in the transarctic journey TRANSARCTICA-2019.
Methods: The subjects were 54 crew members of the journey “TRANSARCTIC-2019” (35 men and 19 women), average age 36 years (range: 20-70). Sampling was carried out at zero point – Arkhangelsk N64°33′ E40°32′, and at a high point – island Hayes N80°34′ E57°41′. TGA parameters were determined: lag phase time (tLag), thrombin peak time (tPeak), thrombin peak (Peak), endogenous thrombin potential (AUC). Statistic were performed using R. The study supported by a grant from the Russian Foundation for Basic Research, project №18-00-00814-COMFI
(18-00-00478).
Results: At a high point, tLag is statistically significantly less (Student´s test, t = 4.358, p-value = 6.364e-5), tPeak is statistically significantly less (Student´s test, t = 4.0495, p-value = 0.0002). AUC is statistically significantly higher at a high point (Student´s test, t = -3.3305, p-value = 0.0016). Peak did not change (Mann-Whitney test V = 593, p-value = 0.3845).
Conclusions: There was shown that under conditions of a trans-latitudinal journey, the time of the lag phase and the time of the formation of a thrombin peak decrease, and the endogenous potential of thrombin increases, which may indicate the formation of a state of hypercoagulation in expedition members at high latitudes. There are needed the further research of the hemostatic system during adaptation to the north climate.
To cite this abstract in AMA style:
Vorobyeva N, Melnichuk E, Beliakov E. Study of Thrombine Generation Assay Parameters of the Crew Trans-Latitude Journey Transartika-2019 [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/study-of-thrombine-generation-assay-parameters-of-the-crew-trans-latitude-journey-transartika-2019/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/study-of-thrombine-generation-assay-parameters-of-the-crew-trans-latitude-journey-transartika-2019/