Abstract Number: PB1791
Meeting: ISTH 2020 Congress
Background: Sexual dysfunction is a common sequel of cancer treatment, affecting the quality of life in women treated with pelvic radiotherapy.
Aims: To evaluate the safety, symptom resolution and objective improvement of the autologous platelet released growth factor (APRGF) injection for treatment of Sexual Dysfunction(SDF) in cited patients.
Methods: This prospective case series study enrolled 10 cancer patients with SDF who underwent pelvic radiotherapy at least 3 years ago. Each patient received 1-2 cc PRFG within three-weeks ( 3 times injection) period . All patients were re-evaluated at eight weeks and six months.
Results: The mean age of participants was 46.90± 7.90 years. 70% of womens were multiparous and 30% were nuligravida. The type of cancer in participants include: rectum 20%, cervix 40%, bladder 20% and endometrial cancer 20%. Radiation type containing brachytherapy in 40% of cases and external radiotherapy in other 60%. 40 % of patients had history of hormone replacement therapy. This study showed that PRFG injection was effective and symptoms had disappeared in all of the patients with significant objective improvements in vaginal diameter (mean of tranvaginal length before and after PRFG injection was 6.5 cm and 7.1 cm respectively (p- value = 0.001). In addition vaginal flexibility improved and mean of flexibility before treatment was 0.72 cm and it increased to 1.85 cm after PRGF injection (P-value = 0.026). Characteristics of discharge before the injection in 60% of patients include dry vagina and 40% had mild discharge and after PRFG injection 40% of patients had moderate and 60% had mild (P-value= 0.190). after the injection of PRFG all of the patients had sexual satisfaction, that was related to TVL, vaginal flexibility and dyscharge.
Conclusions: Overally, our patients reported a better sexual and vaginal function indexes after APRFG injection.
To cite this abstract in AMA style:Mohammadi S, Samaie Nouroozi A, Seidi Zadeh O, Nikbakht M, Bagherian M, Musavi SA. Successful Improvement Sexual Dysfunction After Pelvic Irradiation by Platelet Growth Factor [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/successful-improvement-sexual-dysfunction-after-pelvic-irradiation-by-platelet-growth-factor/. Accessed November 30, 2021.
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