Abstract Number: PB2103
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » Cancer Associated Thrombosis
Background: Cancer patients have an increased risk of developing a venous thromboembolism (VTE) and this combination is reported to result in poorer survival compared to cancer alone.
Aims: To investigate the impact of VTE on the survival of cancer patients in a general population.
Methods: The Scandinavian Thrombosis and Cancer (STAC) cohort, a population-based cohort including 144,952 subjects without previous VTE or cancer was used. During follow-up, cancer and VTE incidences were registered. ‘Cancer-related VTE’ was defined as VTE diagnosed in patients with overt or occult cancer. Survival of subjects without cancer or VTE (‘disease-free subjects’) was compared with survival of subjects diagnosed with cancer and cancer-related VTE. Cox-regression models with cancer and VTE as time-varying exposures were performed to calculate hazard ratios for death. Sub-analyses were performed across different cancer types and stages.
Results: During follow-up (mean 11.7 years) 14,621 subjects developed cancer and 2,444 developed VTE, of which 1241 where cancer-related. The mortality rates (per 100 person-years) for disease-free subjects, VTE only, cancer only and cancer-related VTE were 0.63 (95% CI 0.62-0.65), 5.0 (95% CI 4.6-5.5), 9.2 (95% CI 9.0-9.5) and 45.3 (95% CI 41.1-50.0), respectively. Compared with cancer patients, the risk of death for cancer-related VTE patients was increased 3.4-fold (95% CI 3.1-3.8). Among all cancer types, the occurrence of a VTE increased the mortality risk 2.8 to 14.7-fold.
Conclusions: In a general population, cancer patients with a VTE had a 3.4-fold increased mortality risk compared to cancer patients without VTE, this effect was seen within all cancer types and stages studied.
To cite this abstract in AMA style:
Crobach MJT, Anijs RJS, Brækken SK, Severinsen MT, Hammerstrøm J, Skille H, Kristensen SR, Paulsen B, Tjønneland A, Versteeg HH, Overvad K, Hansen J-, Næss IA, Cannegieter SC. Survival after Cancer-related Venous Thrombosis: The Scandinavian Thrombosis and Cancer Study (STAC) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/survival-after-cancer-related-venous-thrombosis-the-scandinavian-thrombosis-and-cancer-study-stac/. Accessed September 29, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/survival-after-cancer-related-venous-thrombosis-the-scandinavian-thrombosis-and-cancer-study-stac/