Abstract Number: PB1140
Meeting: ISTH 2020 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Management of Bleeding and Trauma
Background: The World Federation of Hemophilia (WFH) has developed the third edition of the WFH Guidelines for the Management of Hemophilia.
Aims: The aim of these guidelines are to provide health care professionals and people with hemophilia recommendations that will guide the management of hemophilia around the world.
Methods: This 2020 version of the WFH treatment guidelines incorporates evidence-based and Trustworthy Consensus-Based Statement (TCBS) approaches in conformance with established international standards for clinical practice guidelines. The TCBS process produces evidence-informed recommendations based on the evidence and expert clinical advice.
Results: Guided by content leads (AS, GP), a guidelines methodology expert (SZL), and 11 chapter leads, the original 7 chapters of the 2012 version of the guidelines were updated and 4 new chapters were added (Table 1). Each chapter was assigned an expert panel composed of up to 10 members, healthcare professionals with clinical expertise, and patients/caregivers, with the latter making up 25% of each chapter panel. A total of 50 panelists were assigned to the 11 chapters, with some panelists serving on more than one panel.
Each chapter topic went through a systematic review of the published literature, and each study was screened for eligibility based on apriori defined criteria on population, interventions, comparisons, and outcomes. Data was extracted from included studies and evidence tables developed. Evidence-based recommendations were drafted by the chapter panel and each set of recommendations went through a Delphi consensus process. The threshold for achieving consensus was 80% agreement among panel voters.
Across all chapters, 344 recommendations achieved consensus. Recommendations not achieving consensus were included as discussion points in the final manuscripts.
Conclusions: This third edition of the WFH Guidelines for the Management of Hemophilia are trustworthy, reliable, evidence-informed, and expert-driven recommendations that will guide the treatment and management of hemophilia around the world.
To cite this abstract in AMA style:
Srivastava A, Pierce G, Zelman Lewis S, Coffin D, Hum D. The 2020 World Federation of Hemophilia Guidelines for the Management of Hemophilia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-2020-world-federation-of-hemophilia-guidelines-for-the-management-of-hemophilia/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-2020-world-federation-of-hemophilia-guidelines-for-the-management-of-hemophilia/