Abstract Number: PB1961
Meeting: ISTH 2020 Congress
Background: Hyperlipidemia is the pathological condition that can caused cell injury which characterized by low level of antioxidant and high level of inflammatory activity, including blood vessel. Synbiotic is the combination of prebiotic and probiotic. Soybean is one of the most potential prebiotics which have an antioxidant properties. Water kefir is a fermented milk which contain high amount of lactic acid bacteria.
Aims: The aim of this study was to determine the antioxidant (MDA and SOD) and antiinflammatory (neutrophil count) effect of soybean water kefir on aortic tissue of hyperlipidemic rats model.
Methods: The research used experimental method with post-test only control group design. The sample of the study were 15 male rats (Rattus norvegicus) aged 2-3 months and weight 180-250 grams. All groups were acclimatized for one week and fed ad libitum for 8 weeks. Group II and III were given quail egg yolk with dose 5 ml/200 grams of body weight for 4 weeks. While group III was given the soybean water kefir with dose of 5 ml/200 grams of body weight for the next 4 weeks. At the end of the study, rats were terminated. Aortic organ were examined for MDA and SOD level, while blood taken in rats tail were examined under light microscope with Wright staining to know the neutrophil count.
Results: Mean of MDA on each group were consecutively 2.48±0.37, 12.17±0.38, 5.48±0.20 nmol/g. Mean of SOD on each group were consecutively 72.34±0.48, 3.29±0.09, 6.14±0.32%. Mean of neutrophil count were 40.33±0.47, 62.51±0.39, 45.56±0.35%, respectively. The one-way ANOVA showed significant difference in MDA, SOD, and Neutrophil count between these group with p=0.00. Bonferroni post hoc test also showed significant comparison between these group with p=0.00.
Conclusions: The soybean water kefir was significantly increase the antioxidant activity and decrease the inflammatory activity in hyperlipidemic rats model (p< 0.05).
To cite this abstract in AMA style:Afifudin M, Marfianti E. The Antioxidant and Antiinflammatory Effect of Synbiotic Beverage from Soybean Water Kerfir on Aortic Tissue of Hyperlipidemic Rats Model [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-antioxidant-and-antiinflammatory-effect-of-synbiotic-beverage-from-soybean-water-kerfir-on-aortic-tissue-of-hyperlipidemic-rats-model/. Accessed January 28, 2022.
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